Synthesis of palau'amide and its diastereomers: confirmation of its stereostructure

Hirokazu Sugiyama, Atsushi Watanabe, Toshiaki Teruya, Kiyotake Suenaga

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Four diastereomers of palau'amide (1-4), a cytotoxic cyclodepsipeptide, were synthesized. The 1H NMR spectrum of 1 was identical to that of natural palau'amide. This established the complete stereostructure of palau'amide.

Original languageEnglish
Pages (from-to)7343-7345
Number of pages3
JournalTetrahedron Letters
Volume50
Issue number52
DOIs
Publication statusPublished - 2009 Dec 30

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Depsipeptides
Nuclear magnetic resonance
palauamide
Proton Magnetic Resonance Spectroscopy

ASJC Scopus subject areas

  • Biochemistry
  • Organic Chemistry
  • Drug Discovery

Cite this

Synthesis of palau'amide and its diastereomers : confirmation of its stereostructure. / Sugiyama, Hirokazu; Watanabe, Atsushi; Teruya, Toshiaki; Suenaga, Kiyotake.

In: Tetrahedron Letters, Vol. 50, No. 52, 30.12.2009, p. 7343-7345.

Research output: Contribution to journalArticle

Sugiyama, Hirokazu ; Watanabe, Atsushi ; Teruya, Toshiaki ; Suenaga, Kiyotake. / Synthesis of palau'amide and its diastereomers : confirmation of its stereostructure. In: Tetrahedron Letters. 2009 ; Vol. 50, No. 52. pp. 7343-7345.
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