Synthesis of ribofuranosyl glycosides of echiguanines A and B, inhibitors of phosphatidylinositol 4-kinase

Kasumi Sanpei; Yoshio Saito; Masaya Imoto; Kazuo Umezawa; Kuniki Kato

doi:10.1016/0960-894X(96)00459-3

Synthesis of ribofuranosyl glycosides of echiguanines A and B, inhibitors of phosphatidylinositol 4-kinase

Kasumi Sanpei, Yoshio Saito, Masaya Imoto, Kazuo Umezawa, Kuniki Kato

Department of Biosciences and Informatics

Research output: Contribution to journal › Article › peer-review

3 Citations (Scopus)

Abstract

The synthesis of ribofuranosyl glycosides of echiguanines A and B, PI 4-kinase inhibitors, was achieved from 2-amino-4-chloropyrrolo[2,3-d]pyrimidine and 2,3-O-isopropylidene-5-O-(t-butyl) dimethylsilyl-α-D-ribofuranosyl chloride. The ribofuranosyl echiguanine A weakly inhibited PI 4-kinase.

Original language	English
Pages (from-to)	2487-2490
Number of pages	4
Journal	Bioorganic and Medicinal Chemistry Letters
Volume	6
Issue number	21
DOIs	https://doi.org/10.1016/0960-894X(96)00459-3
Publication status	Published - 1996 Nov 5

ASJC Scopus subject areas

Biochemistry
Molecular Medicine
Molecular Biology
Pharmaceutical Science
Drug Discovery
Clinical Biochemistry
Organic Chemistry

Access to Document

10.1016/0960-894X(96)00459-3

Cite this

@article{8dcbab2f71d0454eb5d23f34111bf7b9,

title = "Synthesis of ribofuranosyl glycosides of echiguanines A and B, inhibitors of phosphatidylinositol 4-kinase",

abstract = "The synthesis of ribofuranosyl glycosides of echiguanines A and B, PI 4-kinase inhibitors, was achieved from 2-amino-4-chloropyrrolo[2,3-d]pyrimidine and 2,3-O-isopropylidene-5-O-(t-butyl) dimethylsilyl-α-D-ribofuranosyl chloride. The ribofuranosyl echiguanine A weakly inhibited PI 4-kinase.",

author = "Kasumi Sanpei and Yoshio Saito and Masaya Imoto and Kazuo Umezawa and Kuniki Kato",

year = "1996",

month = nov,

day = "5",

doi = "10.1016/0960-894X(96)00459-3",

language = "English",

volume = "6",

pages = "2487--2490",

journal = "Bioorganic and Medicinal Chemistry Letters",

issn = "0960-894X",

publisher = "Elsevier Limited",

number = "21",

}

TY - JOUR

T1 - Synthesis of ribofuranosyl glycosides of echiguanines A and B, inhibitors of phosphatidylinositol 4-kinase

AU - Sanpei, Kasumi

AU - Saito, Yoshio

AU - Imoto, Masaya

AU - Umezawa, Kazuo

AU - Kato, Kuniki

PY - 1996/11/5

Y1 - 1996/11/5

N2 - The synthesis of ribofuranosyl glycosides of echiguanines A and B, PI 4-kinase inhibitors, was achieved from 2-amino-4-chloropyrrolo[2,3-d]pyrimidine and 2,3-O-isopropylidene-5-O-(t-butyl) dimethylsilyl-α-D-ribofuranosyl chloride. The ribofuranosyl echiguanine A weakly inhibited PI 4-kinase.

AB - The synthesis of ribofuranosyl glycosides of echiguanines A and B, PI 4-kinase inhibitors, was achieved from 2-amino-4-chloropyrrolo[2,3-d]pyrimidine and 2,3-O-isopropylidene-5-O-(t-butyl) dimethylsilyl-α-D-ribofuranosyl chloride. The ribofuranosyl echiguanine A weakly inhibited PI 4-kinase.

UR - http://www.scopus.com/inward/record.url?scp=0030571291&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0030571291&partnerID=8YFLogxK

U2 - 10.1016/0960-894X(96)00459-3

DO - 10.1016/0960-894X(96)00459-3

M3 - Article

AN - SCOPUS:0030571291

SN - 0960-894X

VL - 6

SP - 2487

EP - 2490

JO - Bioorganic and Medicinal Chemistry Letters

JF - Bioorganic and Medicinal Chemistry Letters

IS - 21

ER -

Synthesis of ribofuranosyl glycosides of echiguanines A and B, inhibitors of phosphatidylinositol 4-kinase

Abstract

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this