Synthesis of ribofuranosyl glycosides of echiguanines A and B, inhibitors of phosphatidylinositol 4-kinase

Kasumi Sanpei, Yoshio Saito, Masaya Imoto, Kazuo Umezawa, Kuniki Kato

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

The synthesis of ribofuranosyl glycosides of echiguanines A and B, PI 4-kinase inhibitors, was achieved from 2-amino-4-chloropyrrolo[2,3-d]pyrimidine and 2,3-O-isopropylidene-5-O-(t-butyl) dimethylsilyl-α-D-ribofuranosyl chloride. The ribofuranosyl echiguanine A weakly inhibited PI 4-kinase.

Original languageEnglish
Pages (from-to)2487-2490
Number of pages4
JournalBioorganic and Medicinal Chemistry Letters
Volume6
Issue number21
DOIs
Publication statusPublished - 1996 Nov 5

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Pharmaceutical Science
  • Drug Discovery
  • Clinical Biochemistry
  • Organic Chemistry

Fingerprint Dive into the research topics of 'Synthesis of ribofuranosyl glycosides of echiguanines A and B, inhibitors of phosphatidylinositol 4-kinase'. Together they form a unique fingerprint.

  • Cite this