Synthesis of ribofuranosyl glycosides of echiguanines A and B, inhibitors of phosphatidylinositol 4-kinase

Kasumi Sanpei, Yoshio Saito, Masaya Imoto, Kazuo Umezawa, Kuniki Kato

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

The synthesis of ribofuranosyl glycosides of echiguanines A and B, PI 4-kinase inhibitors, was achieved from 2-amino-4-chloropyrrolo[2,3-d]pyrimidine and 2,3-O-isopropylidene-5-O-(t-butyl) dimethylsilyl-α-D-ribofuranosyl chloride. The ribofuranosyl echiguanine A weakly inhibited PI 4-kinase.

Original languageEnglish
Pages (from-to)2487-2490
Number of pages4
JournalBioorganic and Medicinal Chemistry Letters
Volume6
Issue number21
DOIs
Publication statusPublished - 1996 Nov 5

Fingerprint

1-Phosphatidylinositol 4-Kinase
Glycosides
Chlorides
echiguanine A
echiguanine B
pyrimidine
propylene

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Organic Chemistry
  • Drug Discovery
  • Pharmaceutical Science

Cite this

Synthesis of ribofuranosyl glycosides of echiguanines A and B, inhibitors of phosphatidylinositol 4-kinase. / Sanpei, Kasumi; Saito, Yoshio; Imoto, Masaya; Umezawa, Kazuo; Kato, Kuniki.

In: Bioorganic and Medicinal Chemistry Letters, Vol. 6, No. 21, 05.11.1996, p. 2487-2490.

Research output: Contribution to journalArticle

Sanpei, Kasumi ; Saito, Yoshio ; Imoto, Masaya ; Umezawa, Kazuo ; Kato, Kuniki. / Synthesis of ribofuranosyl glycosides of echiguanines A and B, inhibitors of phosphatidylinositol 4-kinase. In: Bioorganic and Medicinal Chemistry Letters. 1996 ; Vol. 6, No. 21. pp. 2487-2490.
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