Synthesis of the c15-c27 portion of venturicidins: A formal total synthesis of venturicidin x

Keiji Tsunashima, Mitsuaki Ide, Hiroshi Kadoi, Aya Hirayama, Masaya Nakata

Research output: Contribution to journalArticlepeer-review

8 Citations (Scopus)

Abstract

The C15-C27 portion of venturicidin X was prepared using substitution reactions of alkyl trifluoromethanesulfonates with a vinylmetal compound followed by homogeneous hydrogenation. Together with our previous synthesis of the C1-C14 portion of venturicidin X, a formal total synthesis of venturicidin X was completed.

Original languageEnglish
Pages (from-to)3607-3611
Number of pages5
JournalTetrahedron Letters
Volume42
Issue number21
DOIs
Publication statusPublished - 2001 May 21

Keywords

  • Hydrogenation
  • Substitution
  • Two-stage coupling process
  • Venturicidins

ASJC Scopus subject areas

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

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