Synthesis of the C17-C27 fragment of bryostatin 3

Tetsuo Obitsu, Ken Ohmori, Yasuyuki Ogawa, Hiroyuki Hosomi, Shigeru Ohba, Shigeru Nishiyama, Shosuke Yamamura

Research output: Contribution to journalArticle

22 Citations (Scopus)

Abstract

The key synthetic intermediate corresponding to the C17 - C27 positions of bryostatin 3, has successfully been synthesized. The newly constructed stereogenic centers were unambiguously confirmed by X-ray crystallographic analysis.

Original languageEnglish
Pages (from-to)7349-7352
Number of pages4
JournalTetrahedron Letters
Volume39
Issue number40
DOIs
Publication statusPublished - 1998 Oct 1

Keywords

  • Biologically active compounds
  • Macrolides
  • Marine metabolites
  • Polyketides

ASJC Scopus subject areas

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

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    Obitsu, T., Ohmori, K., Ogawa, Y., Hosomi, H., Ohba, S., Nishiyama, S., & Yamamura, S. (1998). Synthesis of the C17-C27 fragment of bryostatin 3. Tetrahedron Letters, 39(40), 7349-7352. https://doi.org/10.1016/S0040-4039(98)01577-9