Synthesis of the naphthalene-derived inhibitors against Cdc25A dual-specificity protein phosphatase and their biological activity

Akiko Shimbashi, Ayako Tsuchiya, Masaya Imoto, Shigeru Nishiyama

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

The synthesis naphthoquinones exhibited stronger activity than the pyranonaphthoquinone-type compound having moderate inhibitory activity against Cdc25A protein phosphatase. The novel naphthalene-type analogues 14 and 18 and the naphthoquinone-type analogues, 8, 9, 15, 16, 19, 21, 22, and 23-28 have been synthesized, and their in vitro Cdc25A phosphatase-inhibitory activity was examined. In assessment of the inhibitory activity, it was revealed that the naphthoquinone core is contributed to the activity, rather than the alkyl side chain.

Original languageEnglish
Pages (from-to)61-65
Number of pages5
JournalBioorganic and Medicinal Chemistry Letters
Volume15
Issue number1
DOIs
Publication statusPublished - 2005 Jan 3

Keywords

  • Biological activity
  • Cdc25A phosphatase inhibitor
  • Cell cycle regulation
  • Dual-specificity phosphatase
  • Naphthoquinone

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Pharmaceutical Science
  • Drug Discovery
  • Clinical Biochemistry
  • Organic Chemistry

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