Synthesis of the naphthalene-derived inhibitors against Cdc25A dual-specificity protein phosphatase and their biological activity

Akiko Shimbashi, Ayako Tsuchiya, Masaya Imoto, Shigeru Nishiyama

Research output: Contribution to journal › Article

5 Citations (Scopus)

Abstract

The synthesis naphthoquinones exhibited stronger activity than the pyranonaphthoquinone-type compound having moderate inhibitory activity against Cdc25A protein phosphatase. The novel naphthalene-type analogues 14 and 18 and the naphthoquinone-type analogues, 8, 9, 15, 16, 19, 21, 22, and 23-28 have been synthesized, and their in vitro Cdc25A phosphatase-inhibitory activity was examined. In assessment of the inhibitory activity, it was revealed that the naphthoquinone core is contributed to the activity, rather than the alkyl side chain.

Original languageEnglish
Pages (from-to)61-65
Number of pages5
JournalBioorganic and Medicinal Chemistry Letters
Volume15
Issue number1
DOIs
Publication statusPublished - 2005 Jan 3

Fingerprint

cdc25 Phosphatases
Dual-Specificity Phosphatases
Naphthoquinones
Phosphoprotein Phosphatases
Bioactivity
naphthalene

Keywords

  • Biological activity
  • Cdc25A phosphatase inhibitor
  • Cell cycle regulation
  • Dual-specificity phosphatase
  • Naphthoquinone

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Organic Chemistry
  • Drug Discovery
  • Pharmaceutical Science

Cite this

Synthesis of the naphthalene-derived inhibitors against Cdc25A dual-specificity protein phosphatase and their biological activity. / Shimbashi, Akiko; Tsuchiya, Ayako; Imoto, Masaya; Nishiyama, Shigeru.

In: Bioorganic and Medicinal Chemistry Letters, Vol. 15, No. 1, 03.01.2005, p. 61-65.

Research output: Contribution to journal › Article

Shimbashi, A, Tsuchiya, A, Imoto, M & Nishiyama, S 2005, 'Synthesis of the naphthalene-derived inhibitors against Cdc25A dual-specificity protein phosphatase and their biological activity', Bioorganic and Medicinal Chemistry Letters, vol. 15, no. 1, pp. 61-65. https://doi.org/10.1016/j.bmcl.2004.10.034
Shimbashi A, Tsuchiya A, Imoto M, Nishiyama S. Synthesis of the naphthalene-derived inhibitors against Cdc25A dual-specificity protein phosphatase and their biological activity. Bioorganic and Medicinal Chemistry Letters. 2005 Jan 3;15(1):61-65. https://doi.org/10.1016/j.bmcl.2004.10.034
Shimbashi, Akiko ; Tsuchiya, Ayako ; Imoto, Masaya ; Nishiyama, Shigeru. / Synthesis of the naphthalene-derived inhibitors against Cdc25A dual-specificity protein phosphatase and their biological activity. In: Bioorganic and Medicinal Chemistry Letters. 2005 ; Vol. 15, No. 1. pp. 61-65.
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