Abstract
The synthesis naphthoquinones exhibited stronger activity than the pyranonaphthoquinone-type compound having moderate inhibitory activity against Cdc25A protein phosphatase. The novel naphthalene-type analogues 14 and 18 and the naphthoquinone-type analogues, 8, 9, 15, 16, 19, 21, 22, and 23-28 have been synthesized, and their in vitro Cdc25A phosphatase-inhibitory activity was examined. In assessment of the inhibitory activity, it was revealed that the naphthoquinone core is contributed to the activity, rather than the alkyl side chain.
| Original language | English |
|---|---|
| Pages (from-to) | 61-65 |
| Number of pages | 5 |
| Journal | Bioorganic and Medicinal Chemistry Letters |
| Volume | 15 |
| Issue number | 1 |
| DOIs | |
| Publication status | Published - 2005 Jan 3 |
Keywords
- Biological activity
- Cdc25A phosphatase inhibitor
- Cell cycle regulation
- Dual-specificity phosphatase
- Naphthoquinone
ASJC Scopus subject areas
- Biochemistry
- Molecular Medicine
- Molecular Biology
- Pharmaceutical Science
- Drug Discovery
- Clinical Biochemistry
- Organic Chemistry
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Cite this
Shimbashi, A., Tsuchiya, A., Imoto, M., & Nishiyama, S. (2005). Synthesis of the naphthalene-derived inhibitors against Cdc25A dual-specificity protein phosphatase and their biological activity. Bioorganic and Medicinal Chemistry Letters, 15(1), 61-65. https://doi.org/10.1016/j.bmcl.2004.10.034