Abstract
Trilobatin [4-(β-D-glucopyranosyloxy)-2,4”,6-trihydroxydihydrochalcone] was synthesized from commercially available naringin in three steps with an overall yield of 30%. The key step was the acid-catalyzed site-selective hydrolysis of terminal α-rhamnopyranosidic linkage in neohesperidose involved in naringin under controlled conditions, by applying a high-pressure steam sterilizer.
| Original language | English |
|---|---|
| Pages (from-to) | 1463-1467 |
| Number of pages | 5 |
| Journal | Bioscience, Biotechnology and Biochemistry |
| Volume | 82 |
| Issue number | 9 |
| DOIs | |
| Publication status | Published - 2018 |
Keywords
- Dihydrochalcone glycoside
- Naringin
- Site-selective hydrolysis
- Trilobatin
ASJC Scopus subject areas
- Biotechnology
- Analytical Chemistry
- Biochemistry
- Applied Microbiology and Biotechnology
- Molecular Biology
- Organic Chemistry
Fingerprint Dive into the research topics of 'Synthesis of trilobatin from naringin via prunin as the key intermediate: Acidic hydrolysis of the α-rhamnosidic linkage in naringin under improved conditions'. Together they form a unique fingerprint.
Cite this
Kurahayashi, K., Hanaya, K., Higashibayashi, S., & Sugai, T. (2018). Synthesis of trilobatin from naringin via prunin as the key intermediate: Acidic hydrolysis of the α-rhamnosidic linkage in naringin under improved conditions. Bioscience, Biotechnology and Biochemistry, 82(9), 1463-1467. https://doi.org/10.1080/09168451.2018.1482455