Synthesis of unsymmetrical Si-rhodamine fluorophores and application to a far-red to near-infrared fluorescence probe for hypoxia

Kenjiro Hanaoka; Yu Kagami; Wen Piao; Takuya Myochin; Koji Numasawa; Yugo Kuriki; Takayuki Ikeno; Tasuku Ueno; Toru Komatsu; Takuya Terai; Tetsuo Nagano; Yasuteru Urano

doi:10.1039/c8cc02451k

Synthesis of unsymmetrical Si-rhodamine fluorophores and application to a far-red to near-infrared fluorescence probe for hypoxia

Kenjiro Hanaoka, Yu Kagami, Wen Piao, Takuya Myochin, Koji Numasawa, Yugo Kuriki, Takayuki Ikeno, Tasuku Ueno, Toru Komatsu, Takuya Terai, Tetsuo Nagano, Yasuteru Urano

Research output: Contribution to journal › Article › peer-review

27 Citations (Scopus)

Abstract

Si-Rhodamines are bright fluorophores with red to near-infrared (NIR) emission, and are widely used for fluorescence imaging of biological phenomena. Here, in order to extend the scope of Si-rhodamine fluorophores, we established a versatile synthesis of unsymmetrical Si-rhodamines. To illustrate its value, we used one of these new fluorophores to synthesize a far-red to NIR fluorescence probe for hypoxia, and showed that it can visualize hepatic ischemia in mice in vivo.

Original language	English
Pages (from-to)	6939-6942
Number of pages	4
Journal	Chemical Communications
Volume	54
Issue number	50
DOIs	https://doi.org/10.1039/c8cc02451k
Publication status	Published - 2018
Externally published	Yes

ASJC Scopus subject areas

Catalysis
Electronic, Optical and Magnetic Materials
Ceramics and Composites
Chemistry(all)
Surfaces, Coatings and Films
Metals and Alloys
Materials Chemistry

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10.1039/c8cc02451k

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@article{1527f4c53fc64cbe84c25edf6712eb3a,

title = "Synthesis of unsymmetrical Si-rhodamine fluorophores and application to a far-red to near-infrared fluorescence probe for hypoxia",

abstract = "Si-Rhodamines are bright fluorophores with red to near-infrared (NIR) emission, and are widely used for fluorescence imaging of biological phenomena. Here, in order to extend the scope of Si-rhodamine fluorophores, we established a versatile synthesis of unsymmetrical Si-rhodamines. To illustrate its value, we used one of these new fluorophores to synthesize a far-red to NIR fluorescence probe for hypoxia, and showed that it can visualize hepatic ischemia in mice in vivo.",

author = "Kenjiro Hanaoka and Yu Kagami and Wen Piao and Takuya Myochin and Koji Numasawa and Yugo Kuriki and Takayuki Ikeno and Tasuku Ueno and Toru Komatsu and Takuya Terai and Tetsuo Nagano and Yasuteru Urano",

note = "Funding Information: This work was supported in part by grants by JSPS KAKENHI Grant Numbers 16H00823, 16H05099 and 18H04609 to K. H., and SENTAN, JST to K. H., who was also supported by Mochida Memorial Foundation for Medical and Pharmaceutical Research. This work was also supported by a grant JSPS Core-to-Core Program, A. Advanced Research Networks. Publisher Copyright: {\textcopyright} 2018 The Royal Society of Chemistry.",

year = "2018",

doi = "10.1039/c8cc02451k",

language = "English",

volume = "54",

pages = "6939--6942",

journal = "Chemical Communications",

issn = "1359-7345",

publisher = "Royal Society of Chemistry",

number = "50",

}

TY - JOUR

T1 - Synthesis of unsymmetrical Si-rhodamine fluorophores and application to a far-red to near-infrared fluorescence probe for hypoxia

AU - Hanaoka, Kenjiro

AU - Kagami, Yu

AU - Piao, Wen

AU - Myochin, Takuya

AU - Numasawa, Koji

AU - Kuriki, Yugo

AU - Ikeno, Takayuki

AU - Ueno, Tasuku

AU - Komatsu, Toru

AU - Terai, Takuya

AU - Nagano, Tetsuo

AU - Urano, Yasuteru

N1 - Funding Information: This work was supported in part by grants by JSPS KAKENHI Grant Numbers 16H00823, 16H05099 and 18H04609 to K. H., and SENTAN, JST to K. H., who was also supported by Mochida Memorial Foundation for Medical and Pharmaceutical Research. This work was also supported by a grant JSPS Core-to-Core Program, A. Advanced Research Networks. Publisher Copyright: © 2018 The Royal Society of Chemistry.

PY - 2018

Y1 - 2018

N2 - Si-Rhodamines are bright fluorophores with red to near-infrared (NIR) emission, and are widely used for fluorescence imaging of biological phenomena. Here, in order to extend the scope of Si-rhodamine fluorophores, we established a versatile synthesis of unsymmetrical Si-rhodamines. To illustrate its value, we used one of these new fluorophores to synthesize a far-red to NIR fluorescence probe for hypoxia, and showed that it can visualize hepatic ischemia in mice in vivo.

AB - Si-Rhodamines are bright fluorophores with red to near-infrared (NIR) emission, and are widely used for fluorescence imaging of biological phenomena. Here, in order to extend the scope of Si-rhodamine fluorophores, we established a versatile synthesis of unsymmetrical Si-rhodamines. To illustrate its value, we used one of these new fluorophores to synthesize a far-red to NIR fluorescence probe for hypoxia, and showed that it can visualize hepatic ischemia in mice in vivo.

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U2 - 10.1039/c8cc02451k

DO - 10.1039/c8cc02451k

M3 - Article

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AN - SCOPUS:85048838837

SN - 1359-7345

VL - 54

SP - 6939

EP - 6942

JO - Chemical Communications

JF - Chemical Communications

IS - 50

ER -

Synthesis of unsymmetrical Si-rhodamine fluorophores and application to a far-red to near-infrared fluorescence probe for hypoxia

Abstract

ASJC Scopus subject areas

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