Synthesis of Various Glycopolymers Bearing Sialyllactose and the Effect of Their Molecular Mobility on Interaction with the Influenza Virus

Masanori Nagao, Teruhiko Matsubara, Yu Hoshino, Toshinori Sato, Yoshiko Miura

Research output: Contribution to journalArticle

Abstract

Synthetic glyco-ligands are promising candidates for effective nanomedicines against pathogens. Glycopolymers bearing sialyl-oligosaccharides interact with hemagglutinin present on the surface of influenza viruses. In designing new glycopolymers that further enhance the interaction with viruses, both static and dynamic properties of the glycopolymers should be considered. In this report, we evaluated the correlation between dynamic properties of glycopolymers and their interaction with the influenza virus. Glycopolymers with pendant sialyllactoses and various linker structures were synthesized, and their molecular mobility was determined by proton spin-spin relaxation time measurements. The molecular mobility of the glycounits increased as the length of the linker structures increased. Interestingly, glycopolymers with the medium-length linker structure exhibited the strongest interaction with the influenza virus, suggesting that optimal molecular mobility is required for maximizing multivalent interactions with the target.

Original languageEnglish
Pages (from-to)2763-2769
Number of pages7
JournalBiomacromolecules
Volume20
Issue number7
DOIs
Publication statusPublished - 2019 Jul 8

Fingerprint

Bearings (structural)
Viruses
Medical nanotechnology
Oligosaccharides
Hemagglutinins
Pathogens
Time measurement
Relaxation time
Protons
Ligands
N-acetylneuraminoyllactose

ASJC Scopus subject areas

  • Bioengineering
  • Biomaterials
  • Polymers and Plastics
  • Materials Chemistry

Cite this

Synthesis of Various Glycopolymers Bearing Sialyllactose and the Effect of Their Molecular Mobility on Interaction with the Influenza Virus. / Nagao, Masanori; Matsubara, Teruhiko; Hoshino, Yu; Sato, Toshinori; Miura, Yoshiko.

In: Biomacromolecules, Vol. 20, No. 7, 08.07.2019, p. 2763-2769.

Research output: Contribution to journalArticle

@article{cc8a0a42b99f494ca3116360b6d510c7,
title = "Synthesis of Various Glycopolymers Bearing Sialyllactose and the Effect of Their Molecular Mobility on Interaction with the Influenza Virus",
abstract = "Synthetic glyco-ligands are promising candidates for effective nanomedicines against pathogens. Glycopolymers bearing sialyl-oligosaccharides interact with hemagglutinin present on the surface of influenza viruses. In designing new glycopolymers that further enhance the interaction with viruses, both static and dynamic properties of the glycopolymers should be considered. In this report, we evaluated the correlation between dynamic properties of glycopolymers and their interaction with the influenza virus. Glycopolymers with pendant sialyllactoses and various linker structures were synthesized, and their molecular mobility was determined by proton spin-spin relaxation time measurements. The molecular mobility of the glycounits increased as the length of the linker structures increased. Interestingly, glycopolymers with the medium-length linker structure exhibited the strongest interaction with the influenza virus, suggesting that optimal molecular mobility is required for maximizing multivalent interactions with the target.",
author = "Masanori Nagao and Teruhiko Matsubara and Yu Hoshino and Toshinori Sato and Yoshiko Miura",
year = "2019",
month = "7",
day = "8",
doi = "10.1021/acs.biomac.9b00515",
language = "English",
volume = "20",
pages = "2763--2769",
journal = "Biomacromolecules",
issn = "1525-7797",
publisher = "American Chemical Society",
number = "7",

}

TY - JOUR

T1 - Synthesis of Various Glycopolymers Bearing Sialyllactose and the Effect of Their Molecular Mobility on Interaction with the Influenza Virus

AU - Nagao, Masanori

AU - Matsubara, Teruhiko

AU - Hoshino, Yu

AU - Sato, Toshinori

AU - Miura, Yoshiko

PY - 2019/7/8

Y1 - 2019/7/8

N2 - Synthetic glyco-ligands are promising candidates for effective nanomedicines against pathogens. Glycopolymers bearing sialyl-oligosaccharides interact with hemagglutinin present on the surface of influenza viruses. In designing new glycopolymers that further enhance the interaction with viruses, both static and dynamic properties of the glycopolymers should be considered. In this report, we evaluated the correlation between dynamic properties of glycopolymers and their interaction with the influenza virus. Glycopolymers with pendant sialyllactoses and various linker structures were synthesized, and their molecular mobility was determined by proton spin-spin relaxation time measurements. The molecular mobility of the glycounits increased as the length of the linker structures increased. Interestingly, glycopolymers with the medium-length linker structure exhibited the strongest interaction with the influenza virus, suggesting that optimal molecular mobility is required for maximizing multivalent interactions with the target.

AB - Synthetic glyco-ligands are promising candidates for effective nanomedicines against pathogens. Glycopolymers bearing sialyl-oligosaccharides interact with hemagglutinin present on the surface of influenza viruses. In designing new glycopolymers that further enhance the interaction with viruses, both static and dynamic properties of the glycopolymers should be considered. In this report, we evaluated the correlation between dynamic properties of glycopolymers and their interaction with the influenza virus. Glycopolymers with pendant sialyllactoses and various linker structures were synthesized, and their molecular mobility was determined by proton spin-spin relaxation time measurements. The molecular mobility of the glycounits increased as the length of the linker structures increased. Interestingly, glycopolymers with the medium-length linker structure exhibited the strongest interaction with the influenza virus, suggesting that optimal molecular mobility is required for maximizing multivalent interactions with the target.

UR - http://www.scopus.com/inward/record.url?scp=85069295255&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85069295255&partnerID=8YFLogxK

U2 - 10.1021/acs.biomac.9b00515

DO - 10.1021/acs.biomac.9b00515

M3 - Article

VL - 20

SP - 2763

EP - 2769

JO - Biomacromolecules

JF - Biomacromolecules

SN - 1525-7797

IS - 7

ER -