Synthesis of verbenachalcone congeners and their biological assessment against activation of the NGF-mediated neurite outgrowth of PC12D cells' activity

Takamasa Tanabe, Takahisa Ogamino, Yoshifumi Shimizu, Masaya Imoto, Shigeru Nishiyama

Research output: Contribution to journalArticle

10 Citations (Scopus)


Synthesis of the verbenachalcone derivatives 3-5 involving littorachalcone 2 from diaryl ether 7 enabled an SAR study of enhancement activity against the NGF-mediated neurite outgrowth from PC12D cells. Littorachalcone 2 and o-deoxyverbenachalcone 5 showed similar activity to that of verbenachalcone 1.

Original languageEnglish
Pages (from-to)2753-2762
Number of pages10
JournalBioorganic and Medicinal Chemistry
Issue number8
Publication statusPublished - 2006 Apr 15



  • Anodic oxidation
  • Littorachalcone
  • NGF-mediated neurite outgrowth
  • Verbena littoralis
  • Verbenachalcone

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Pharmaceutical Science
  • Drug Discovery
  • Clinical Biochemistry
  • Organic Chemistry

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