Synthesis of verbenachalcone congeners and their biological assessment against activation of the NGF-mediated neurite outgrowth of PC12D cells' activity

Takamasa Tanabe; Takahisa Ogamino; Yoshifumi Shimizu; Masaya Imoto; Shigeru Nishiyama

doi:10.1016/j.bmc.2005.11.055

Synthesis of verbenachalcone congeners and their biological assessment against activation of the NGF-mediated neurite outgrowth of PC12D cells' activity

Takamasa Tanabe, Takahisa Ogamino, Yoshifumi Shimizu, Masaya Imoto, Shigeru Nishiyama

Research output: Contribution to journal › Article › peer-review

7 Citations (Scopus)

Abstract

Synthesis of the verbenachalcone derivatives 3-5 involving littorachalcone 2 from diaryl ether 7 enabled an SAR study of enhancement activity against the NGF-mediated neurite outgrowth from PC12D cells. Littorachalcone 2 and o-deoxyverbenachalcone 5 showed similar activity to that of verbenachalcone 1.

Original language	English
Pages (from-to)	2753-2762
Number of pages	10
Journal	Bioorganic and Medicinal Chemistry
Volume	14
Issue number	8
DOIs	https://doi.org/10.1016/j.bmc.2005.11.055
Publication status	Published - 2006 Apr 15
Externally published	Yes

Keywords

Anodic oxidation
Littorachalcone
NGF-mediated neurite outgrowth
Verbena littoralis
Verbenachalcone

ASJC Scopus subject areas

Biochemistry
Molecular Medicine
Molecular Biology
Pharmaceutical Science
Drug Discovery
Clinical Biochemistry
Organic Chemistry

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10.1016/j.bmc.2005.11.055

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title = "Synthesis of verbenachalcone congeners and their biological assessment against activation of the NGF-mediated neurite outgrowth of PC12D cells' activity",

abstract = "Synthesis of the verbenachalcone derivatives 3-5 involving littorachalcone 2 from diaryl ether 7 enabled an SAR study of enhancement activity against the NGF-mediated neurite outgrowth from PC12D cells. Littorachalcone 2 and o-deoxyverbenachalcone 5 showed similar activity to that of verbenachalcone 1.",

keywords = "Anodic oxidation, Littorachalcone, NGF-mediated neurite outgrowth, Verbena littoralis, Verbenachalcone",

author = "Takamasa Tanabe and Takahisa Ogamino and Yoshifumi Shimizu and Masaya Imoto and Shigeru Nishiyama",

note = "Funding Information: This work was supported by a Grant-in-Aid for the 21st Century COE program {\textquoteleft}Keio Life Conjugated Chemistry{\textquoteright}, as well as Scientific Research C from the Ministry of Education, Culture, Sports, Science and Technology, Japan. The authors were indebted to Mr. Y. Shimizu of their Faculty for his technical assistance.",

year = "2006",

month = apr,

day = "15",

doi = "10.1016/j.bmc.2005.11.055",

language = "English",

volume = "14",

pages = "2753--2762",

journal = "Bioorganic and Medicinal Chemistry",

issn = "0968-0896",

publisher = "Elsevier Limited",

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T1 - Synthesis of verbenachalcone congeners and their biological assessment against activation of the NGF-mediated neurite outgrowth of PC12D cells' activity

AU - Tanabe, Takamasa

AU - Ogamino, Takahisa

AU - Shimizu, Yoshifumi

AU - Imoto, Masaya

AU - Nishiyama, Shigeru

N1 - Funding Information: This work was supported by a Grant-in-Aid for the 21st Century COE program ‘Keio Life Conjugated Chemistry’, as well as Scientific Research C from the Ministry of Education, Culture, Sports, Science and Technology, Japan. The authors were indebted to Mr. Y. Shimizu of their Faculty for his technical assistance.

PY - 2006/4/15

Y1 - 2006/4/15

N2 - Synthesis of the verbenachalcone derivatives 3-5 involving littorachalcone 2 from diaryl ether 7 enabled an SAR study of enhancement activity against the NGF-mediated neurite outgrowth from PC12D cells. Littorachalcone 2 and o-deoxyverbenachalcone 5 showed similar activity to that of verbenachalcone 1.

AB - Synthesis of the verbenachalcone derivatives 3-5 involving littorachalcone 2 from diaryl ether 7 enabled an SAR study of enhancement activity against the NGF-mediated neurite outgrowth from PC12D cells. Littorachalcone 2 and o-deoxyverbenachalcone 5 showed similar activity to that of verbenachalcone 1.

KW - Anodic oxidation

KW - Littorachalcone

KW - NGF-mediated neurite outgrowth

KW - Verbena littoralis

KW - Verbenachalcone

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EP - 2762

JO - Bioorganic and Medicinal Chemistry

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IS - 8

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Synthesis of verbenachalcone congeners and their biological assessment against activation of the NGF-mediated neurite outgrowth of PC12D cells' activity

Abstract

Keywords

ASJC Scopus subject areas

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