Synthesis of verbenachalcone congeners and their biological assessment against activation of the NGF-mediated neurite outgrowth of PC12D cells' activity

Takamasa Tanabe, Takahisa Ogamino, Yoshifumi Shimizu, Masaya Imoto, Shigeru Nishiyama

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

Synthesis of the verbenachalcone derivatives 3-5 involving littorachalcone 2 from diaryl ether 7 enabled an SAR study of enhancement activity against the NGF-mediated neurite outgrowth from PC12D cells. Littorachalcone 2 and o-deoxyverbenachalcone 5 showed similar activity to that of verbenachalcone 1.

Original languageEnglish
Pages (from-to)2753-2762
Number of pages10
JournalBioorganic and Medicinal Chemistry
Volume14
Issue number8
DOIs
Publication statusPublished - 2006 Apr 15

Fingerprint

Nerve Growth Factor
Chemical activation
Ether
Derivatives
verbenachalcone
Neuronal Outgrowth

Keywords

  • Anodic oxidation
  • Littorachalcone
  • NGF-mediated neurite outgrowth
  • Verbena littoralis
  • Verbenachalcone

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Organic Chemistry
  • Drug Discovery
  • Pharmaceutical Science

Cite this

Synthesis of verbenachalcone congeners and their biological assessment against activation of the NGF-mediated neurite outgrowth of PC12D cells' activity. / Tanabe, Takamasa; Ogamino, Takahisa; Shimizu, Yoshifumi; Imoto, Masaya; Nishiyama, Shigeru.

In: Bioorganic and Medicinal Chemistry, Vol. 14, No. 8, 15.04.2006, p. 2753-2762.

Research output: Contribution to journalArticle

@article{5a147211397c47a6a324832a7f6bd1cc,
title = "Synthesis of verbenachalcone congeners and their biological assessment against activation of the NGF-mediated neurite outgrowth of PC12D cells' activity",
abstract = "Synthesis of the verbenachalcone derivatives 3-5 involving littorachalcone 2 from diaryl ether 7 enabled an SAR study of enhancement activity against the NGF-mediated neurite outgrowth from PC12D cells. Littorachalcone 2 and o-deoxyverbenachalcone 5 showed similar activity to that of verbenachalcone 1.",
keywords = "Anodic oxidation, Littorachalcone, NGF-mediated neurite outgrowth, Verbena littoralis, Verbenachalcone",
author = "Takamasa Tanabe and Takahisa Ogamino and Yoshifumi Shimizu and Masaya Imoto and Shigeru Nishiyama",
year = "2006",
month = "4",
day = "15",
doi = "10.1016/j.bmc.2005.11.055",
language = "English",
volume = "14",
pages = "2753--2762",
journal = "Bioorganic and Medicinal Chemistry",
issn = "0968-0896",
publisher = "Elsevier Limited",
number = "8",

}

TY - JOUR

T1 - Synthesis of verbenachalcone congeners and their biological assessment against activation of the NGF-mediated neurite outgrowth of PC12D cells' activity

AU - Tanabe, Takamasa

AU - Ogamino, Takahisa

AU - Shimizu, Yoshifumi

AU - Imoto, Masaya

AU - Nishiyama, Shigeru

PY - 2006/4/15

Y1 - 2006/4/15

N2 - Synthesis of the verbenachalcone derivatives 3-5 involving littorachalcone 2 from diaryl ether 7 enabled an SAR study of enhancement activity against the NGF-mediated neurite outgrowth from PC12D cells. Littorachalcone 2 and o-deoxyverbenachalcone 5 showed similar activity to that of verbenachalcone 1.

AB - Synthesis of the verbenachalcone derivatives 3-5 involving littorachalcone 2 from diaryl ether 7 enabled an SAR study of enhancement activity against the NGF-mediated neurite outgrowth from PC12D cells. Littorachalcone 2 and o-deoxyverbenachalcone 5 showed similar activity to that of verbenachalcone 1.

KW - Anodic oxidation

KW - Littorachalcone

KW - NGF-mediated neurite outgrowth

KW - Verbena littoralis

KW - Verbenachalcone

UR - http://www.scopus.com/inward/record.url?scp=33644761818&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=33644761818&partnerID=8YFLogxK

U2 - 10.1016/j.bmc.2005.11.055

DO - 10.1016/j.bmc.2005.11.055

M3 - Article

C2 - 16377199

AN - SCOPUS:33644761818

VL - 14

SP - 2753

EP - 2762

JO - Bioorganic and Medicinal Chemistry

JF - Bioorganic and Medicinal Chemistry

SN - 0968-0896

IS - 8

ER -