Synthesis of (+)-vinblastine and its analogues

Tohru Miyazaki, Satoshi Yokoshima, Siro Simizu, Hiroyuki Osada, Hidetoshi Tokuyama, Tohru Fukuyama

Research output: Contribution to journalArticle

57 Citations (Scopus)

Abstract

(Chemical Equation Presented) A synthetic route to vinblastine and its analogues with an ethynyl group, which features a stereoselective coupling of an 11-membered key intermediate with vindoline, is described. Transformations of the alkynyl moiety including a partial reduction as well as a Sonogashira coupling furnished a variety of analogues.

Original languageEnglish
Pages (from-to)4737-4740
Number of pages4
JournalOrganic Letters
Volume9
Issue number23
DOIs
Publication statusPublished - 2007 Nov 8
Externally publishedYes

ASJC Scopus subject areas

  • Biochemistry
  • Physical and Theoretical Chemistry
  • Organic Chemistry

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  • Cite this

    Miyazaki, T., Yokoshima, S., Simizu, S., Osada, H., Tokuyama, H., & Fukuyama, T. (2007). Synthesis of (+)-vinblastine and its analogues. Organic Letters, 9(23), 4737-4740. https://doi.org/10.1021/ol702040y