(Chemical Equation Presented) A synthetic route to vinblastine and its analogues with an ethynyl group, which features a stereoselective coupling of an 11-membered key intermediate with vindoline, is described. Transformations of the alkynyl moiety including a partial reduction as well as a Sonogashira coupling furnished a variety of analogues.
|Number of pages||4|
|Publication status||Published - 2007 Nov 8|
ASJC Scopus subject areas
- Physical and Theoretical Chemistry
- Organic Chemistry