Synthetic bioluminescent coelenterazine derivatives

Ryo Nishihara, Daniel Citterio, Koji Suzuki

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

The development of coelenterazine (CTZ) derivatives resulting in superior optical characteristics is an efficient method to extend the range of its possible applications. Here, we describe the synthesis of three C-6 substituted CTZ derivatives retaining the recognition by Renilla luciferase (RLuc) and its derivatives. The novel derivatives are useful as bright blue-shifted CTZ derivatives, which can be used as an alternative to hitherto reported compound DeepBlueC™.

Original languageEnglish
Title of host publicationMethods in Molecular Biology
PublisherHumana Press Inc.
Pages19-31
Number of pages13
Volume1461
DOIs
Publication statusPublished - 2016

Publication series

NameMethods in Molecular Biology
Volume1461
ISSN (Print)10643745

Keywords

  • Bioluminescence
  • Chemiluminescence
  • Coelenterazine (CTZ)
  • DeepBlueC
  • Luciferase
  • Luciferin
  • Renilla luciferase (RLuc)

ASJC Scopus subject areas

  • Molecular Biology
  • Genetics

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  • Cite this

    Nishihara, R., Citterio, D., & Suzuki, K. (2016). Synthetic bioluminescent coelenterazine derivatives. In Methods in Molecular Biology (Vol. 1461, pp. 19-31). (Methods in Molecular Biology; Vol. 1461). Humana Press Inc.. https://doi.org/10.1007/978-1-4939-3813-1_2