Synthetic studies of erythromycin derivatives syntheses and antimicrobial activities of 3'-epi-erythromycin A and (9S)-11-dehydroxy-9-deoxo-9-hydroxy-11-oxoerythromycin A

M. Nakata, T. Tamai, Y. Miura, M. Kinosita, K. Tatsuta

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Two new derivatives, 3'-epi-erythromycin A (2) and (9S)-11-dehydroxy-9-deoxo-9-hydroxy-11-oxoerythromycin A (3), have been synthesized by using glycosylation with glycal (Ferrier rearrangement), bromomethoxylation and bis(tributyltin) oxide-bromine oxidation as the key steps. Their antimicrobial activities were compared with those of erythromycin A (1).

Original languageEnglish
Pages (from-to)813-826
Number of pages14
JournalJournal of Antibiotics
Volume46
Issue number5
Publication statusPublished - 1993

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bis(tri-n-butyltin)oxide
Erythromycin
Bromine
Glycosylation
11-dehydroxy-9-deoxo-9-hydroxy-11-oxoerythromycin A

ASJC Scopus subject areas

  • Molecular Medicine
  • Pharmacology

Cite this

Synthetic studies of erythromycin derivatives syntheses and antimicrobial activities of 3'-epi-erythromycin A and (9S)-11-dehydroxy-9-deoxo-9-hydroxy-11-oxoerythromycin A. / Nakata, M.; Tamai, T.; Miura, Y.; Kinosita, M.; Tatsuta, K.

In: Journal of Antibiotics, Vol. 46, No. 5, 1993, p. 813-826.

Research output: Contribution to journalArticle

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