Synthetic studies of erythromycin derivatives syntheses and antimicrobial activities of 3”-Epi-erythromycin A and (9S) 11-dehydroxy-9-deoxo-9-hydroxy-11-oxoerythromycin A

Masaya Nakata, Tetsuro Tamai, Yukiko Miura, Mitsuhiro Kinoshita, Kuniaki Tatsuta

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Two new derivatives, 3”-epi-erythromycin A (2) and (9S)-11-dehydroxy-9-deoxo-9-hydroxy-11-oxoerythromycin A (3), have been synthesized by using glycosylation with glycal (Ferrier rearrangement), bromomethoxylation and bis(tributyltin) oxide-bromine oxidation as the key steps. Their antimicrobial activities were compared with those of erythromycin A (1).

Original languageEnglish
Pages (from-to)813-826
Number of pages14
JournalJournal of Antibiotics
Volume46
Issue number5
DOIs
Publication statusPublished - 1993 May

ASJC Scopus subject areas

  • Pharmacology
  • Drug Discovery

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