TY - JOUR
T1 - Synthetic studies of erythromycins. III. Total synthesis of erythronolide a through (9s)-9-dihydroerythronolide A
AU - Kinoshita, Mitsuhiro
AU - Arai, Masayuki
AU - Ohsawa, Naoki
AU - Nakata, Masaya
N1 - Funding Information:
Acknowledgment: We are grateful1 to Prof. S. Umezawa, Institute of Bioorganic Chemistry, and Prof. H. Dmezawa, Institute of Microbial Chemistry for their generous support of our program. Financial support by the Ministry of Education, Science, and Culture (Grant-in-Aid for Special Research) and by the Japan Antibiotics Research Association Research Grant are deeply acknowledged. We are also indebted to Miss Koyama of the Institute for 250 MHz lo-NMR spectral analyses, and Mr. K. Inoshita for technical assistance.
PY - 1986
Y1 - 1986
N2 - Erythronolide A (1) was enantiospecifically synthesized through (9S)-9-dihydroerythronolide A (2) from the chiral C-10-C-13, C-7-C-9, and C-1-C-6 synthetic segments, 3, 5, and 4, respectively. The overall yield of 1 from 4 was 1.84% in 21 steps.
AB - Erythronolide A (1) was enantiospecifically synthesized through (9S)-9-dihydroerythronolide A (2) from the chiral C-10-C-13, C-7-C-9, and C-1-C-6 synthetic segments, 3, 5, and 4, respectively. The overall yield of 1 from 4 was 1.84% in 21 steps.
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U2 - 10.1016/S0040-4039(00)84383-X
DO - 10.1016/S0040-4039(00)84383-X
M3 - Article
AN - SCOPUS:0022643037
SN - 0040-4039
VL - 27
SP - 1815
EP - 1818
JO - Tetrahedron Letters
JF - Tetrahedron Letters
IS - 16
ER -