Synthetic studies of erythromycins. III. Total synthesis of erythronolide a through (9s)-9-dihydroerythronolide A

Mitsuhiro Kinoshita, Masayuki Arai, Naoki Ohsawa, Masaya Nakata

Research output: Contribution to journalArticle

31 Citations (Scopus)

Abstract

Erythronolide A (1) was enantiospecifically synthesized through (9S)-9-dihydroerythronolide A (2) from the chiral C-10-C-13, C-7-C-9, and C-1-C-6 synthetic segments, 3, 5, and 4, respectively. The overall yield of 1 from 4 was 1.84% in 21 steps.

Original languageEnglish
Pages (from-to)1815-1818
Number of pages4
JournalTetrahedron Letters
Volume27
Issue number16
DOIs
Publication statusPublished - 1986

ASJC Scopus subject areas

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

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