Synthetic studies of mangostin derivatives with an inhibitory activity on PDGF-induced human aortic smooth cells proliferation

Yuko Nishihama, Takahisa Ogamino, Wen Lei Shi, Byung Yoon Cha, Takayuki Yonezawa, Toshiaki Teruya, Kazuo Nagai, Kiyotake Suenaga, Je Tae Woo, Shigeru Nishiyama

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6 Citations (Scopus)

Abstract

The mangostin derivatives 310, were synthesized by halogenation, electrochemical oxidation, and mCPBA oxidation of α- and γ-mangostins (1, 2). Among them, the hydroxyl 9 and the benzopyran 10 derivatives produced by mCPBA, showed remarkable antiproliferative activities against human aortic smooth muscle cells (HASMC) induced by platelet-derived growth factor (PDGF).

Original languageEnglish
Pages (from-to)759-765
Number of pages7
JournalHeterocycles
Volume77
Issue number2
DOIs
Publication statusPublished - 2009 Feb 1

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Keywords

  • Electrochemical Oxidation
  • Human Aortic Smooth Muscle Cell
  • Mangostin
  • mCPBA Oxidation
  • Xanthone

ASJC Scopus subject areas

  • Analytical Chemistry
  • Organic Chemistry
  • Pharmacology

Cite this

Nishihama, Y., Ogamino, T., Shi, W. L., Cha, B. Y., Yonezawa, T., Teruya, T., Nagai, K., Suenaga, K., Woo, J. T., & Nishiyama, S. (2009). Synthetic studies of mangostin derivatives with an inhibitory activity on PDGF-induced human aortic smooth cells proliferation. Heterocycles, 77(2), 759-765. https://doi.org/10.3987/COM-08-S(F)65