Synthetic studies of mangostin derivatives with an inhibitory activity on PDGF-induced human aortic smooth cells proliferation

Yuko Nishihama; Takahisa Ogamino; Wen Lei Shi; Byung Yoon Cha; Takayuki Yonezawa; Toshiaki Teruya; Kazuo Nagai; Kiyotake Suenaga; Je Tae Woo; Shigeru Nishiyama

doi:10.3987/COM-08-S(F)65

Synthetic studies of mangostin derivatives with an inhibitory activity on PDGF-induced human aortic smooth cells proliferation

Yuko Nishihama, Takahisa Ogamino, Wen Lei Shi, Byung Yoon Cha, Takayuki Yonezawa, Toshiaki Teruya, Kazuo Nagai, Kiyotake Suenaga, Je Tae Woo, Shigeru Nishiyama

Department of Chemistry

Research output: Contribution to journal › Article › peer-review

7 Citations (Scopus)

Abstract

The mangostin derivatives 310, were synthesized by halogenation, electrochemical oxidation, and mCPBA oxidation of α- and γ-mangostins (1, 2). Among them, the hydroxyl 9 and the benzopyran 10 derivatives produced by mCPBA, showed remarkable antiproliferative activities against human aortic smooth muscle cells (HASMC) induced by platelet-derived growth factor (PDGF).

Original language	English
Pages (from-to)	759-765
Number of pages	7
Journal	Heterocycles
Volume	77
Issue number	2
DOIs	https://doi.org/10.3987/COM-08-S(F)65
Publication status	Published - 2009 Feb 1

Keywords

Electrochemical Oxidation
Human Aortic Smooth Muscle Cell
Mangostin
Xanthone
mCPBA Oxidation

ASJC Scopus subject areas

Analytical Chemistry
Pharmacology
Organic Chemistry

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abstract = "The mangostin derivatives 310, were synthesized by halogenation, electrochemical oxidation, and mCPBA oxidation of α- and γ-mangostins (1, 2). Among them, the hydroxyl 9 and the benzopyran 10 derivatives produced by mCPBA, showed remarkable antiproliferative activities against human aortic smooth muscle cells (HASMC) induced by platelet-derived growth factor (PDGF).",

keywords = "Electrochemical Oxidation, Human Aortic Smooth Muscle Cell, Mangostin, Xanthone, mCPBA Oxidation",

author = "Yuko Nishihama and Takahisa Ogamino and Shi, {Wen Lei} and Cha, {Byung Yoon} and Takayuki Yonezawa and Toshiaki Teruya and Kazuo Nagai and Kiyotake Suenaga and Woo, {Je Tae} and Shigeru Nishiyama",

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doi = "10.3987/COM-08-S(F)65",

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T1 - Synthetic studies of mangostin derivatives with an inhibitory activity on PDGF-induced human aortic smooth cells proliferation

AU - Nishihama, Yuko

AU - Ogamino, Takahisa

AU - Shi, Wen Lei

AU - Cha, Byung Yoon

AU - Yonezawa, Takayuki

AU - Teruya, Toshiaki

AU - Nagai, Kazuo

AU - Suenaga, Kiyotake

AU - Woo, Je Tae

AU - Nishiyama, Shigeru

PY - 2009/2/1

Y1 - 2009/2/1

N2 - The mangostin derivatives 310, were synthesized by halogenation, electrochemical oxidation, and mCPBA oxidation of α- and γ-mangostins (1, 2). Among them, the hydroxyl 9 and the benzopyran 10 derivatives produced by mCPBA, showed remarkable antiproliferative activities against human aortic smooth muscle cells (HASMC) induced by platelet-derived growth factor (PDGF).

AB - The mangostin derivatives 310, were synthesized by halogenation, electrochemical oxidation, and mCPBA oxidation of α- and γ-mangostins (1, 2). Among them, the hydroxyl 9 and the benzopyran 10 derivatives produced by mCPBA, showed remarkable antiproliferative activities against human aortic smooth muscle cells (HASMC) induced by platelet-derived growth factor (PDGF).

KW - Electrochemical Oxidation

KW - Human Aortic Smooth Muscle Cell

KW - Mangostin

KW - Xanthone

KW - mCPBA Oxidation

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Synthetic studies of mangostin derivatives with an inhibitory activity on PDGF-induced human aortic smooth cells proliferation

Abstract

Keywords

ASJC Scopus subject areas

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