Synthetic studies of mangostin derivatives with an inhibitory activity on PDGF-induced human aortic smooth cells proliferation

Yuko Nishihama, Takahisa Ogamino, Wen Lei Shi, Byung Yoon Cha, Takayuki Yonezawa, Toshiaki Teruya, Kazuo Nagai, Kiyotake Suenaga, Je Tae Woo, Shigeru Nishiyama

Research output: Contribution to journalArticlepeer-review

6 Citations (Scopus)

Abstract

The mangostin derivatives 310, were synthesized by halogenation, electrochemical oxidation, and mCPBA oxidation of α- and γ-mangostins (1, 2). Among them, the hydroxyl 9 and the benzopyran 10 derivatives produced by mCPBA, showed remarkable antiproliferative activities against human aortic smooth muscle cells (HASMC) induced by platelet-derived growth factor (PDGF).

Original languageEnglish
Pages (from-to)759-765
Number of pages7
JournalHeterocycles
Volume77
Issue number2
DOIs
Publication statusPublished - 2009 Feb 1

Keywords

  • Electrochemical Oxidation
  • Human Aortic Smooth Muscle Cell
  • Mangostin
  • Xanthone
  • mCPBA Oxidation

ASJC Scopus subject areas

  • Analytical Chemistry
  • Pharmacology
  • Organic Chemistry

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