Synthetic studies of rifamycins. VI. Preparation and elaboration of the aromatic segment for the synthesis of rifamycin W

Masaya Nakata, Mitsuhiro Kinoshita, Shigeru Ohba, Yoshihiko Saito

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

A convenient preparation of the aromatic segment 3 starting from 3,5-dibromo-2,6-dimethoxytoluene 5 and furan was described along with the elaboration of 3 by the aldol coupling with the aliphatic segment 2 to the synthetic precursor 4 of rifamycin W.

Original languageEnglish
Pages (from-to)1373-1376
Number of pages4
JournalTetrahedron Letters
Volume25
Issue number13
DOIs
Publication statusPublished - 1984

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Rifamycins
furan
dimethoxytoluene
3-hydroxybutanal
rifamycin SV

ASJC Scopus subject areas

  • Biochemistry
  • Organic Chemistry
  • Drug Discovery

Cite this

Synthetic studies of rifamycins. VI. Preparation and elaboration of the aromatic segment for the synthesis of rifamycin W. / Nakata, Masaya; Kinoshita, Mitsuhiro; Ohba, Shigeru; Saito, Yoshihiko.

In: Tetrahedron Letters, Vol. 25, No. 13, 1984, p. 1373-1376.

Research output: Contribution to journalArticle

Nakata, Masaya ; Kinoshita, Mitsuhiro ; Ohba, Shigeru ; Saito, Yoshihiko. / Synthetic studies of rifamycins. VI. Preparation and elaboration of the aromatic segment for the synthesis of rifamycin W. In: Tetrahedron Letters. 1984 ; Vol. 25, No. 13. pp. 1373-1376.
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