TY - JOUR
T1 - Synthetic studies of rifamycins. VII.1) a facile synthesis of the aromatic chromophore of rifamycin s through a rifamycin W aromatic segment
AU - Nakata, Masaya
AU - Wada, Shigeru
AU - Tatsuta, Kuniaki
AU - Kinoshita, Mitsuhiro
N1 - Publisher Copyright:
© 1985 The Chemical Society of Japan.
PY - 1985
Y1 - 1985
N2 - The intact aromatic chromophore of rifamycin S, 7-amino-2,5-dihydroxy-2,4-dimethyl-naphtho[2,l-6]furan-l,6,9(2H)-trione, was synthesized through the rifamycin W aromatic segment, l-[5,8-dimethoxy-2,4-bis-(methoxymethoxy)-3-methyl-6-nitro-l-naphthyl]-l-propanone which was prepared in 9 steps and 29.6% overall yield from 2,6-bis(benzyloxy)-3,5-dibromotoluene and furan.
AB - The intact aromatic chromophore of rifamycin S, 7-amino-2,5-dihydroxy-2,4-dimethyl-naphtho[2,l-6]furan-l,6,9(2H)-trione, was synthesized through the rifamycin W aromatic segment, l-[5,8-dimethoxy-2,4-bis-(methoxymethoxy)-3-methyl-6-nitro-l-naphthyl]-l-propanone which was prepared in 9 steps and 29.6% overall yield from 2,6-bis(benzyloxy)-3,5-dibromotoluene and furan.
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U2 - 10.1246/bcsj.58.1801
DO - 10.1246/bcsj.58.1801
M3 - Article
AN - SCOPUS:0022004795
SN - 0009-2673
VL - 58
SP - 1801
EP - 1806
JO - Bulletin of the Chemical Society of Japan
JF - Bulletin of the Chemical Society of Japan
IS - 6
ER -