Synthetic studies of zoanthamine/norzoanthamine alkaloids: Advanced intermediate for the heterocyclic aminal core

Naotsuka Hikage, Hironori Furukawa, Kenichi Takao, Susumu Kobayashi

Research output: Contribution to journalArticle

37 Citations (Scopus)

Abstract

An advanced intermediate for the heterocyclic aminal core of zoanthamine/norzoanthamine alkaloids was prepared in an enantio and stereoselective manner. Contiguous quaternary chiral centers were selectively constructed utilizing a stereoselective cuprate addition to the readily available (+)-Wieland-Miescher ketone.

Original languageEnglish
Pages (from-to)6237-6240
Number of pages4
JournalTetrahedron Letters
Volume39
Issue number34
DOIs
Publication statusPublished - 1998 Aug 20
Externally publishedYes

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Ketones
Alkaloids
norzoanthamine
zoanthamine

Keywords

  • Alkaloids;animals;amino;ketones;marine metabolites

ASJC Scopus subject areas

  • Biochemistry
  • Organic Chemistry
  • Drug Discovery

Cite this

Synthetic studies of zoanthamine/norzoanthamine alkaloids : Advanced intermediate for the heterocyclic aminal core. / Hikage, Naotsuka; Furukawa, Hironori; Takao, Kenichi; Kobayashi, Susumu.

In: Tetrahedron Letters, Vol. 39, No. 34, 20.08.1998, p. 6237-6240.

Research output: Contribution to journalArticle

Hikage, Naotsuka ; Furukawa, Hironori ; Takao, Kenichi ; Kobayashi, Susumu. / Synthetic studies of zoanthamine/norzoanthamine alkaloids : Advanced intermediate for the heterocyclic aminal core. In: Tetrahedron Letters. 1998 ; Vol. 39, No. 34. pp. 6237-6240.
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