An advanced intermediate for the heterocyclic aminal core of zoanthamine/norzoanthamine alkaloids was prepared in an enantio and stereoselective manner. Contiguous quaternary chiral centers were selectively constructed utilizing a stereoselective cuprate addition to the readily available (+)-Wieland-Miescher ketone.
- Alkaloids;animals;amino;ketones;marine metabolites
ASJC Scopus subject areas
- Drug Discovery
- Organic Chemistry