Synthetic studies of zoanthamine/norzoanthamine: Biogenetic-like one-step construction of the heterocyclic aminal core (CDEFG ring) from a monocyclic precursor

Naotsuka Hikage, Hironori Furukawa, Ken Ichi Takao, Kobayashi Susumu

Research output: Contribution to journalArticle

30 Citations (Scopus)

Abstract

Biogenetic-like one-step construction of the pentacyclic aminal core of zoanthamine/norzoanthamine alkaloids was accomplished in high yield from the suitably protected monocyclic aminohydroxy diketocarboxylic acid 7 by heating in aqueous acetic acid.

Original languageEnglish
Pages (from-to)1370-1372
Number of pages3
JournalChemical and Pharmaceutical Bulletin
Volume48
Issue number9
DOIs
Publication statusPublished - 2000 Jan 1

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Keywords

  • Alkaloid
  • Aminal
  • Norzoanthamine
  • Polycycle
  • Tandem reaction

ASJC Scopus subject areas

  • Chemistry(all)
  • Drug Discovery

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