Synthetic studies on apoptolidin

Synthesis of the C1-C21 macrolide fragment

Kazunobu Toshima, Tsuyoshi Arita, Koji Kato, Daisuke Tanaka, Shuichi Matsumura

Research output: Contribution to journalArticle

49 Citations (Scopus)

Abstract

The stereoselective and convergent synthesis of the C1-C21 macrocyclic segment (2) of the apoptosis inducing macrolide antibiotic, apoptolidin (1), is described.

Original languageEnglish
Pages (from-to)8873-8876
Number of pages4
JournalTetrahedron Letters
Volume42
Issue number50
DOIs
Publication statusPublished - 2001 Dec 10

Fingerprint

Macrolides
Apoptosis
Anti-Bacterial Agents
apoptolidin

Keywords

  • Apoptolidin
  • Apoptosis
  • Macrocyclization
  • Macrolide

ASJC Scopus subject areas

  • Biochemistry
  • Organic Chemistry
  • Drug Discovery

Cite this

Synthetic studies on apoptolidin : Synthesis of the C1-C21 macrolide fragment. / Toshima, Kazunobu; Arita, Tsuyoshi; Kato, Koji; Tanaka, Daisuke; Matsumura, Shuichi.

In: Tetrahedron Letters, Vol. 42, No. 50, 10.12.2001, p. 8873-8876.

Research output: Contribution to journalArticle

Toshima, Kazunobu ; Arita, Tsuyoshi ; Kato, Koji ; Tanaka, Daisuke ; Matsumura, Shuichi. / Synthetic studies on apoptolidin : Synthesis of the C1-C21 macrolide fragment. In: Tetrahedron Letters. 2001 ; Vol. 42, No. 50. pp. 8873-8876.
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