Synthetic studies on apoptolidin: Synthesis of the C1-C21 macrolide fragment

Kazunobu Toshima, Tsuyoshi Arita, Koji Kato, Daisuke Tanaka, Shuichi Matsumura

Research output: Contribution to journalArticle

49 Citations (Scopus)

Abstract

The stereoselective and convergent synthesis of the C1-C21 macrocyclic segment (2) of the apoptosis inducing macrolide antibiotic, apoptolidin (1), is described.

Original languageEnglish
Pages (from-to)8873-8876
Number of pages4
JournalTetrahedron Letters
Volume42
Issue number50
DOIs
Publication statusPublished - 2001 Dec 10

Keywords

  • Apoptolidin
  • Apoptosis
  • Macrocyclization
  • Macrolide

ASJC Scopus subject areas

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

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