Synthetic studies on concanamycin A: Total synthesis of concanolide A (concanamycin F)

Takaaki Jyojima, Naoki Miyamoto, Masataka Katohno, Masaya Nakata, Shuichi Matsumura, Kazunobu Toshima

Research output: Contribution to journalArticle

24 Citations (Scopus)

Abstract

Enantioselective first total synthesis of concanolide A (concanamycin F), which is one of a new class of macrolide antibiotics, concanamycins, has been achieved by a highly effective and convergent route.

Original languageEnglish
Pages (from-to)6007-6010
Number of pages4
JournalTetrahedron Letters
Volume39
Issue number33
DOIs
Publication statusPublished - 1998 Aug 13

Keywords

  • Aldol reaction
  • Concanamycin F
  • Concanolide A
  • Lactonization, Stille reaction
  • Vacular H -ATPase inhibitor

ASJC Scopus subject areas

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

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