Synthetic Studies on FNC-RED and Its Analogues Containing an All syn-Cyclopentanetetrol Moiety

Shinsuke Inuki; Keisuke Sato; Naoto Zui; Ryosuke Yamaguchi; Takanori Matsumaru; Yukari Fujimoto

doi:10.1021/acs.joc.9b02101

Synthetic Studies on FNC-RED and Its Analogues Containing an All syn-Cyclopentanetetrol Moiety

Shinsuke Inuki, Keisuke Sato, Naoto Zui, Ryosuke Yamaguchi, Takanori Matsumaru, Yukari Fujimoto

Department of Chemistry

Research output: Contribution to journal › Article

Abstract

FNC-RED exhibits innate immune receptor Toll-like receptor 4 (TLR4)/myeloid differentiation factor-2 (MD2) stimulatory activity. We have developed a divergent synthetic route to FNC-RED derivatives containing various alkyl side chains. Key features of the synthetic study include stepwise palladium catalyzed cross-coupling reactions and the construction of an all syn-cyclopentanetetrol moiety.

Original language	English
Pages (from-to)	12680-12685
Number of pages	6
Journal	Journal of Organic Chemistry
Volume	84
Issue number	19
DOIs	https://doi.org/10.1021/acs.joc.9b02101
Publication status	Published - 2019 Oct 4

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ASJC Scopus subject areas

Organic Chemistry

Cite this

Inuki, S., Sato, K., Zui, N., Yamaguchi, R., Matsumaru, T., & Fujimoto, Y. (2019). Synthetic Studies on FNC-RED and Its Analogues Containing an All syn-Cyclopentanetetrol Moiety. Journal of Organic Chemistry, 84(19), 12680-12685. https://doi.org/10.1021/acs.joc.9b02101

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Access to Document

10.1021/acs.joc.9b02101