Abstract
FNC-RED exhibits innate immune receptor Toll-like receptor 4 (TLR4)/myeloid differentiation factor-2 (MD2) stimulatory activity. We have developed a divergent synthetic route to FNC-RED derivatives containing various alkyl side chains. Key features of the synthetic study include stepwise palladium catalyzed cross-coupling reactions and the construction of an all syn-cyclopentanetetrol moiety.
| Original language | English |
|---|---|
| Pages (from-to) | 12680-12685 |
| Number of pages | 6 |
| Journal | Journal of Organic Chemistry |
| Volume | 84 |
| Issue number | 19 |
| DOIs | |
| Publication status | Published - 2019 Oct 4 |
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ASJC Scopus subject areas
- Organic Chemistry
Cite this
Synthetic Studies on FNC-RED and Its Analogues Containing an All syn-Cyclopentanetetrol Moiety. / Inuki, Shinsuke; Sato, Keisuke; Zui, Naoto; Yamaguchi, Ryosuke; Matsumaru, Takanori; Fujimoto, Yukari.
In: Journal of Organic Chemistry, Vol. 84, No. 19, 04.10.2019, p. 12680-12685.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Synthetic Studies on FNC-RED and Its Analogues Containing an All syn-Cyclopentanetetrol Moiety
AU - Inuki, Shinsuke
AU - Sato, Keisuke
AU - Zui, Naoto
AU - Yamaguchi, Ryosuke
AU - Matsumaru, Takanori
AU - Fujimoto, Yukari
PY - 2019/10/4
Y1 - 2019/10/4
N2 - FNC-RED exhibits innate immune receptor Toll-like receptor 4 (TLR4)/myeloid differentiation factor-2 (MD2) stimulatory activity. We have developed a divergent synthetic route to FNC-RED derivatives containing various alkyl side chains. Key features of the synthetic study include stepwise palladium catalyzed cross-coupling reactions and the construction of an all syn-cyclopentanetetrol moiety.
AB - FNC-RED exhibits innate immune receptor Toll-like receptor 4 (TLR4)/myeloid differentiation factor-2 (MD2) stimulatory activity. We have developed a divergent synthetic route to FNC-RED derivatives containing various alkyl side chains. Key features of the synthetic study include stepwise palladium catalyzed cross-coupling reactions and the construction of an all syn-cyclopentanetetrol moiety.
UR - http://www.scopus.com/inward/record.url?scp=85072945696&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85072945696&partnerID=8YFLogxK
U2 - 10.1021/acs.joc.9b02101
DO - 10.1021/acs.joc.9b02101
M3 - Article
C2 - 31507185
AN - SCOPUS:85072945696
VL - 84
SP - 12680
EP - 12685
JO - Journal of Organic Chemistry
JF - Journal of Organic Chemistry
SN - 0022-3263
IS - 19
ER -