Abstract
FNC-RED exhibits innate immune receptor Toll-like receptor 4 (TLR4)/myeloid differentiation factor-2 (MD2) stimulatory activity. We have developed a divergent synthetic route to FNC-RED derivatives containing various alkyl side chains. Key features of the synthetic study include stepwise palladium catalyzed cross-coupling reactions and the construction of an all syn-cyclopentanetetrol moiety.
Original language | English |
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Pages (from-to) | 12680-12685 |
Number of pages | 6 |
Journal | Journal of Organic Chemistry |
Volume | 84 |
Issue number | 19 |
DOIs | |
Publication status | Published - 2019 Oct 4 |
ASJC Scopus subject areas
- Organic Chemistry