Synthetic Studies on FNC-RED and Its Analogues Containing an All syn-Cyclopentanetetrol Moiety

Shinsuke Inuki, Keisuke Sato, Naoto Zui, Ryosuke Yamaguchi, Takanori Matsumaru, Yukari Fujimoto

Research output: Contribution to journalArticle

Abstract

FNC-RED exhibits innate immune receptor Toll-like receptor 4 (TLR4)/myeloid differentiation factor-2 (MD2) stimulatory activity. We have developed a divergent synthetic route to FNC-RED derivatives containing various alkyl side chains. Key features of the synthetic study include stepwise palladium catalyzed cross-coupling reactions and the construction of an all syn-cyclopentanetetrol moiety.

Original languageEnglish
Pages (from-to)12680-12685
Number of pages6
JournalJournal of Organic Chemistry
Volume84
Issue number19
DOIs
Publication statusPublished - 2019 Oct 4

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Toll-Like Receptor 4
Palladium
Derivatives

ASJC Scopus subject areas

  • Organic Chemistry

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Synthetic Studies on FNC-RED and Its Analogues Containing an All syn-Cyclopentanetetrol Moiety. / Inuki, Shinsuke; Sato, Keisuke; Zui, Naoto; Yamaguchi, Ryosuke; Matsumaru, Takanori; Fujimoto, Yukari.

In: Journal of Organic Chemistry, Vol. 84, No. 19, 04.10.2019, p. 12680-12685.

Research output: Contribution to journalArticle

Inuki, Shinsuke ; Sato, Keisuke ; Zui, Naoto ; Yamaguchi, Ryosuke ; Matsumaru, Takanori ; Fujimoto, Yukari. / Synthetic Studies on FNC-RED and Its Analogues Containing an All syn-Cyclopentanetetrol Moiety. In: Journal of Organic Chemistry. 2019 ; Vol. 84, No. 19. pp. 12680-12685.
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