Synthetic Studies on FNC-RED and Its Analogues Containing an All syn-Cyclopentanetetrol Moiety

Shinsuke Inuki, Keisuke Sato, Naoto Zui, Ryosuke Yamaguchi, Takanori Matsumaru, Yukari Fujimoto

Research output: Contribution to journalArticle

Abstract

FNC-RED exhibits innate immune receptor Toll-like receptor 4 (TLR4)/myeloid differentiation factor-2 (MD2) stimulatory activity. We have developed a divergent synthetic route to FNC-RED derivatives containing various alkyl side chains. Key features of the synthetic study include stepwise palladium catalyzed cross-coupling reactions and the construction of an all syn-cyclopentanetetrol moiety.

Original languageEnglish
Pages (from-to)12680-12685
Number of pages6
JournalJournal of Organic Chemistry
Volume84
Issue number19
DOIs
Publication statusPublished - 2019 Oct 4

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ASJC Scopus subject areas

  • Organic Chemistry

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