Synthetic Studies on FNC-RED and Its Analogues Containing an All syn-Cyclopentanetetrol Moiety

Shinsuke Inuki; Keisuke Sato; Naoto Zui; Ryosuke Yamaguchi; Takanori Matsumaru; Yukari Fujimoto

doi:10.1021/acs.joc.9b02101

Synthetic Studies on FNC-RED and Its Analogues Containing an All syn-Cyclopentanetetrol Moiety

Shinsuke Inuki, Keisuke Sato, Naoto Zui, Ryosuke Yamaguchi, Takanori Matsumaru, Yukari Fujimoto

Department of Chemistry

Research output: Contribution to journal › Article › peer-review

Abstract

FNC-RED exhibits innate immune receptor Toll-like receptor 4 (TLR4)/myeloid differentiation factor-2 (MD2) stimulatory activity. We have developed a divergent synthetic route to FNC-RED derivatives containing various alkyl side chains. Key features of the synthetic study include stepwise palladium catalyzed cross-coupling reactions and the construction of an all syn-cyclopentanetetrol moiety.

Original language	English
Pages (from-to)	12680-12685
Number of pages	6
Journal	Journal of Organic Chemistry
Volume	84
Issue number	19
DOIs	https://doi.org/10.1021/acs.joc.9b02101
Publication status	Published - 2019 Oct 4

ASJC Scopus subject areas

Organic Chemistry

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abstract = "FNC-RED exhibits innate immune receptor Toll-like receptor 4 (TLR4)/myeloid differentiation factor-2 (MD2) stimulatory activity. We have developed a divergent synthetic route to FNC-RED derivatives containing various alkyl side chains. Key features of the synthetic study include stepwise palladium catalyzed cross-coupling reactions and the construction of an all syn-cyclopentanetetrol moiety.",

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AU - Inuki, Shinsuke

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AU - Zui, Naoto

AU - Yamaguchi, Ryosuke

AU - Matsumaru, Takanori

AU - Fujimoto, Yukari

PY - 2019/10/4

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AB - FNC-RED exhibits innate immune receptor Toll-like receptor 4 (TLR4)/myeloid differentiation factor-2 (MD2) stimulatory activity. We have developed a divergent synthetic route to FNC-RED derivatives containing various alkyl side chains. Key features of the synthetic study include stepwise palladium catalyzed cross-coupling reactions and the construction of an all syn-cyclopentanetetrol moiety.

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