Synthetic studies on glycosphingolipids from protostomia phyla: Synthesis of glycosphingolipids from the parasite Schistosoma mansoni

Takayuki Kanaya, Satomi Yagi, Frank Schweizer, Tadahiro Takeda, Fumiyuki Kiuchi, Noriyasu Hada

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Synthetic access to three neutral glycosphingolipids from the parasite Schistosoma mansoni adult worm has been achieved. These structures differ significantly from those of other parasites and exhibit a unique structural motif termed "schisto-core" consisting of GalNAcb 1→4Glcβ 1→sequence. We have synthesized glycosphi-ngolipids, β-D-GalNAcp- (1→4)-β-D-Glcp-(1→1)Cer (1), β-D-GlcNAcp-(1→3)-β- D-GalNAcp-(1→4)-β-D-Glcp-(1→1)Cer (2) and β-D-Galp- (1→4)-β-D-GlcNAcp-(1→3)-β-D-GalNAcp-(1→4) -β-D-Glcp-(1→1)Cer (3).

Original languageEnglish
Pages (from-to)811-817
Number of pages7
JournalChemical and Pharmaceutical Bulletin
Volume58
Issue number6
DOIs
Publication statusPublished - 2010 Jun

Keywords

  • Chemical synthesis
  • Glycosphingolipid
  • Schisto-core
  • Schistosoma mansoni

ASJC Scopus subject areas

  • Chemistry(all)
  • Drug Discovery

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