TY - JOUR
T1 - Synthetic studies on glycosphingolipids from Protostomia phyla
T2 - syntheses and biological activities of amphoteric glycolipids containing a phosphocholine residue from the earthworm Pheretima hilgendorfi
AU - Hada, Noriyasu
AU - Shida, Yukihiko
AU - Shimamura, Hiroshi
AU - Sonoda, Yoshiko
AU - Kasahara, Tadashi
AU - Sugita, Mutsumi
AU - Takeda, Tadahiro
PY - 2008/9/8
Y1 - 2008/9/8
N2 - Two types of amphoteric glycosphingolipid found in the earthworm Pheretima hilgendorfi, PC(→6)-β-d-Galp-(1→6)-β-d-Galp-(1→1)Cer (1) and PC(→6)-β-d-Galp-(1→6)-β-d-Galp-(1→6)-β-d-Galp-(1→1)Cer (2), and their derivatives (4, 5) were synthesized. These were examined for their ability to enhance production of interleukin-8 (IL-8), a potent inflammatory cytokine involved in neutrophil chemotaxis, in a TNFα-stimulated granulocytic HL-60 cells. Compounds 1 and 2 were found to be potent enhancers of IL-8 production.
AB - Two types of amphoteric glycosphingolipid found in the earthworm Pheretima hilgendorfi, PC(→6)-β-d-Galp-(1→6)-β-d-Galp-(1→1)Cer (1) and PC(→6)-β-d-Galp-(1→6)-β-d-Galp-(1→6)-β-d-Galp-(1→1)Cer (2), and their derivatives (4, 5) were synthesized. These were examined for their ability to enhance production of interleukin-8 (IL-8), a potent inflammatory cytokine involved in neutrophil chemotaxis, in a TNFα-stimulated granulocytic HL-60 cells. Compounds 1 and 2 were found to be potent enhancers of IL-8 production.
KW - Amphoteric glycosphingolipid
KW - IL-8 production
KW - Pheretima hilgendorfi
KW - Phosphocholine
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U2 - 10.1016/j.carres.2008.05.001
DO - 10.1016/j.carres.2008.05.001
M3 - Article
C2 - 18513707
AN - SCOPUS:48349104015
VL - 343
SP - 2221
EP - 2228
JO - Carbohydrate Research
JF - Carbohydrate Research
SN - 0008-6215
IS - 13
ER -