Abstract
Two types of amphoteric glycosphingolipid found in the earthworm Pheretima hilgendorfi, PC(→6)-β-d-Galp-(1→6)-β-d-Galp-(1→1)Cer (1) and PC(→6)-β-d-Galp-(1→6)-β-d-Galp-(1→6)-β-d-Galp-(1→1)Cer (2), and their derivatives (4, 5) were synthesized. These were examined for their ability to enhance production of interleukin-8 (IL-8), a potent inflammatory cytokine involved in neutrophil chemotaxis, in a TNFα-stimulated granulocytic HL-60 cells. Compounds 1 and 2 were found to be potent enhancers of IL-8 production.
| Original language | English |
|---|---|
| Pages (from-to) | 2221-2228 |
| Number of pages | 8 |
| Journal | Carbohydrate Research |
| Volume | 343 |
| Issue number | 13 |
| DOIs | |
| Publication status | Published - 2008 Sep 8 |
Keywords
- Amphoteric glycosphingolipid
- IL-8 production
- Pheretima hilgendorfi
- Phosphocholine
ASJC Scopus subject areas
- Analytical Chemistry
- Biochemistry
- Organic Chemistry
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Cite this
Hada, N., Shida, Y., Shimamura, H., Sonoda, Y., Kasahara, T., Sugita, M., & Takeda, T. (2008). Synthetic studies on glycosphingolipids from Protostomia phyla: syntheses and biological activities of amphoteric glycolipids containing a phosphocholine residue from the earthworm Pheretima hilgendorfi. Carbohydrate Research, 343(13), 2221-2228. https://doi.org/10.1016/j.carres.2008.05.001