TY - JOUR
T1 - Synthetic studies on glycosphingolipids from Protostomia phyla
T2 - syntheses and biological activities of amphoteric glycolipids containing a phosphocholine residue from the earthworm Pheretima hilgendorfi
AU - Hada, Noriyasu
AU - Shida, Yukihiko
AU - Shimamura, Hiroshi
AU - Sonoda, Yoshiko
AU - Kasahara, Tadashi
AU - Sugita, Mutsumi
AU - Takeda, Tadahiro
N1 - Funding Information:
This work was supported by a Grant-in-Aid for Scientific Research (No. 19590011) from the Ministry of Education, Culture, Sports, Science and Technology of Japan (MEXT), and Open Research Center project of the MEXT. The authors are grateful to Ms. J. Hada for providing HR-FAB MS data.
PY - 2008/9/8
Y1 - 2008/9/8
N2 - Two types of amphoteric glycosphingolipid found in the earthworm Pheretima hilgendorfi, PC(→6)-β-d-Galp-(1→6)-β-d-Galp-(1→1)Cer (1) and PC(→6)-β-d-Galp-(1→6)-β-d-Galp-(1→6)-β-d-Galp-(1→1)Cer (2), and their derivatives (4, 5) were synthesized. These were examined for their ability to enhance production of interleukin-8 (IL-8), a potent inflammatory cytokine involved in neutrophil chemotaxis, in a TNFα-stimulated granulocytic HL-60 cells. Compounds 1 and 2 were found to be potent enhancers of IL-8 production.
AB - Two types of amphoteric glycosphingolipid found in the earthworm Pheretima hilgendorfi, PC(→6)-β-d-Galp-(1→6)-β-d-Galp-(1→1)Cer (1) and PC(→6)-β-d-Galp-(1→6)-β-d-Galp-(1→6)-β-d-Galp-(1→1)Cer (2), and their derivatives (4, 5) were synthesized. These were examined for their ability to enhance production of interleukin-8 (IL-8), a potent inflammatory cytokine involved in neutrophil chemotaxis, in a TNFα-stimulated granulocytic HL-60 cells. Compounds 1 and 2 were found to be potent enhancers of IL-8 production.
KW - Amphoteric glycosphingolipid
KW - IL-8 production
KW - Pheretima hilgendorfi
KW - Phosphocholine
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U2 - 10.1016/j.carres.2008.05.001
DO - 10.1016/j.carres.2008.05.001
M3 - Article
C2 - 18513707
AN - SCOPUS:48349104015
SN - 0008-6215
VL - 343
SP - 2221
EP - 2228
JO - Carbohydrate Research
JF - Carbohydrate Research
IS - 13
ER -