Synthetic studies on polymaxenolides: Model studies for constructing dihydropyran portion and synthesis of lower portion

Yutaka Matsuda, Masaya Kato, Tomonori Kawaguchi, Takayuki Koyama, Yoko Saikawa, Masaya Nakata

Research output: Contribution to journalArticle

7 Citations (Scopus)


With a goal of the total synthesis of polymaxenolide, the first hybrid marine natural product, the model studies for constructing the dihydropyran portion based on the originally proposed biosynthesis (C-C bond formation followed by dehydrative cyclization) and the synthesis of the lower portion (the C1-C3, C7-C17 portion) based on an iodide-induced Morita-Baylis-Hillman type reaction (a three-component assembly) followed by Suzuki-Miyaura cross-coupling are described.

Original languageEnglish
Pages (from-to)1154-1168
Number of pages15
Issue number6
Publication statusPublished - 2014 Feb 11



  • Dehydrative cyclization
  • Morita-Baylis-Hillman reaction
  • Polymaxenolide
  • Suzuki-Miyaura cross-coupling

ASJC Scopus subject areas

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

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