Synthetic studies on reidispongiolide A, an actin-depolymerizing marine macrolide

synthesis of C11-C22 and C23-C35 segments

Satoshi Akiyama, Eisuke Toriihara, Kazushi Suzuki, Toshiaki Teruya, Kiyotake Suenaga

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

The C11-C22 and C23-C35 segments 2 and 3 of reidispongiolide A (1), an actin-depolymerizing marine macrolide, were synthesized enantioselectively in 12 steps from (R)-glycidyl trityl ether and in 12 steps from chiral ketone 15, respectively.

Original languageEnglish
Pages (from-to)5012-5014
Number of pages3
JournalTetrahedron Letters
Volume50
Issue number35
DOIs
Publication statusPublished - 2009 Sep 2

Fingerprint

Macrolides
Ketones
Ether
Actins
reidispongiolide A
glycidyl ethers

ASJC Scopus subject areas

  • Biochemistry
  • Organic Chemistry
  • Drug Discovery

Cite this

Synthetic studies on reidispongiolide A, an actin-depolymerizing marine macrolide : synthesis of C11-C22 and C23-C35 segments. / Akiyama, Satoshi; Toriihara, Eisuke; Suzuki, Kazushi; Teruya, Toshiaki; Suenaga, Kiyotake.

In: Tetrahedron Letters, Vol. 50, No. 35, 02.09.2009, p. 5012-5014.

Research output: Contribution to journalArticle

Akiyama, Satoshi ; Toriihara, Eisuke ; Suzuki, Kazushi ; Teruya, Toshiaki ; Suenaga, Kiyotake. / Synthetic studies on reidispongiolide A, an actin-depolymerizing marine macrolide : synthesis of C11-C22 and C23-C35 segments. In: Tetrahedron Letters. 2009 ; Vol. 50, No. 35. pp. 5012-5014.
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