Synthetic studies on the thiostrepton family of peptide antibiotics: Synthesis of the tetrasubstituted dehydropiperidine and piperidine cores

Syuhei Higashibayashi, Kimiko Hashimoto, Masaya Nakata

Research output: Contribution to journalArticle

28 Citations (Scopus)

Abstract

The tetrasubstituted dehydropiperidine and piperidine cores of the thiostrepton family of peptide antibiotics were synthesized which featured the coupling between the azomethine ylide and the enantiopure sulfinimine, and the subsequent stereoselective reduction of the six-membered imine.

Original languageEnglish
Pages (from-to)105-110
Number of pages6
JournalTetrahedron Letters
Volume43
Issue number1
DOIs
Publication statusPublished - 2002 Jan 1

Keywords

  • Piperidines
  • Stereoselective reduction
  • Sulfinimines
  • Thiostrepton

ASJC Scopus subject areas

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

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