Abstract
The tetrasubstituted dehydropiperidine and piperidine cores of the thiostrepton family of peptide antibiotics were synthesized which featured the coupling between the azomethine ylide and the enantiopure sulfinimine, and the subsequent stereoselective reduction of the six-membered imine.
Original language | English |
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Pages (from-to) | 105-110 |
Number of pages | 6 |
Journal | Tetrahedron Letters |
Volume | 43 |
Issue number | 1 |
DOIs | |
Publication status | Published - 2002 Jan 1 |
Keywords
- Piperidines
- Stereoselective reduction
- Sulfinimines
- Thiostrepton
ASJC Scopus subject areas
- Biochemistry
- Drug Discovery
- Organic Chemistry