Synthetic studies on thiostrepton family of peptide antibiotics: Synthesis of the tetrasubstituted dihydroquinoline portion of siomycin D1

Syuhei Higashibayashi, Tomonori Mori, Kazuyuki Shinko, Kimiko Hashimoto, Masaya Nakata

Research output: Contribution to journalArticle

25 Citations (Scopus)

Abstract

The tetrasubstituted dihydroquinoline portion of siomycin D1, a member of the thiostrepton family of peptide antibiotics, was synthesized from 5,6,7,8-tetrahydroquinoline featuring the modified Reissert-Henze reaction, the homolytic aromatic substitution reaction, the modified Boekelheide rearrangement, and the Jacobsen asymmetric epoxidation.

Original languageEnglish
Pages (from-to)111-122
Number of pages12
JournalHeterocycles
Volume57
Issue number1
Publication statusPublished - 2002 Jan 1

ASJC Scopus subject areas

  • Analytical Chemistry
  • Pharmacology
  • Organic Chemistry

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