In order to establish the stereochemistry of akaterpin, a specific inhibitor of PI-PLC, synthesis of cis-decalin 2 and trans-decalin 3 was carried out. Comparison of NMR spectra of 2 and 3 with that of akaterpin indicated that the upper decalin has a cis-fused structure.
- Intramolecular Diels-Alder reaction
- Reductive alkylation
ASJC Scopus subject areas
- Drug Discovery
- Organic Chemistry