Synthetic study of akaterpin: Determination of the relative stereochemistry of the upper decalin moiety with disulfated hydroquinone

Nobuyuki Kawai, Ken ichi Takao, Susumu Kobayashi

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

In order to establish the stereochemistry of akaterpin, a specific inhibitor of PI-PLC, synthesis of cis-decalin 2 and trans-decalin 3 was carried out. Comparison of NMR spectra of 2 and 3 with that of akaterpin indicated that the upper decalin has a cis-fused structure.

Original languageEnglish
Pages (from-to)4193-4196
Number of pages4
JournalTetrahedron Letters
Volume40
Issue number22
DOIs
Publication statusPublished - 1999 May 28

Keywords

  • Akaterpin
  • Cis-decalin
  • Intramolecular Diels-Alder reaction
  • Reductive alkylation
  • Trans-decalin

ASJC Scopus subject areas

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

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