Synthetic study of macquarimicins: Highly stereoselective construction of the AB-ring system

Ryosuke Munakata, Tatsuo Ueki, Hironori Katakai, Ken Ichi Takao, Kin Ichi Tadano

Research output: Contribution to journalArticle

32 Citations (Scopus)

Abstract

matrix presented The highly stereoselective synthesis of the AB-ring system of macquarimicins, a novel class of microbial metabolites with inhibitory activity for neutral sphingomyelinase, has been achieved. The present synthesis features the highly stereocontrolled construction of the cis-tetrahydroindan structure via the intramolecular Diels-Alder reaction of an (E,Z,E)-1,6,8-nonatriene derived from D-glyceraldehyde acetonide.

Original languageEnglish
Pages (from-to)3029-3032
Number of pages4
JournalOrganic Letters
Volume3
Issue number19
DOIs
Publication statusPublished - 2001 Sep 20

ASJC Scopus subject areas

  • Biochemistry
  • Physical and Theoretical Chemistry
  • Organic Chemistry

Fingerprint Dive into the research topics of 'Synthetic study of macquarimicins: Highly stereoselective construction of the AB-ring system'. Together they form a unique fingerprint.

  • Cite this