Systematizing and cloning of genes involved in the cerebellar cortex circuit development

Teiichi Furuichi, Yoko Shiraishi-Yamaguchi, Akira Sato, Tetsushi Sadakata, Jinhong Huang, Yo Shinoda, Kanehiro Hayashi, Yuriko Mishima, Mineko Tomomura, Hirozumi Nishibe, Fumio Yoshikawa

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

The cerebellar cortical circuit of mammals develops via a series of magnificent cellular events in the postnatal stage of development to accomplish the formation of functional circuit architectures. The contribution of genetic factors is thought to be crucial to cerebellar development. Therefore, it is essential to analyze the underlying transcriptome during development to understand the genetic blueprint of the cerebellar cortical circuit. In this review, we introduce the profiling of large numbers of spatiotemporal gene expression data obtained by developmental time-series microarray analyses and in situ hybridization cellular mRNA mapping, and the creation of a neuroinformatics database called the Cerebellar Development Transcriptome Database. Using this database, we have identified thousands of genes that are classified into various functional categories and are expressed coincidently with related cellular developmental stages. We have also suggested the molecular mechanisms of cerebellar development by functional characterization of several identified genes (Cupidin, p130Cas, very-KIND, CAPS2) responsible for distinct cellular events of developing cerebellar granule cells. Taken together, the gene expression profiling during the cerebellar development demonstrates that the development of cerebellar cortical circuit is attributed to the complex but orchestrated transcriptome.

Original languageEnglish
Pages (from-to)1241-1252
Number of pages12
JournalNeurochemical Research
Volume36
Issue number7
DOIs
Publication statusPublished - 2011 Jul
Externally publishedYes

Fingerprint

Cerebellar Cortex
Cloning
Organism Cloning
Genes
Gene Expression Profiling
Databases
Transcriptome
Networks (circuits)
Gene expression
Microarray Analysis
Blueprints
Mammals
In Situ Hybridization
Microarrays
Gene Expression
Time series
Messenger RNA

Keywords

  • CAPS2/Cadps2
  • CDT-DB
  • Cupidin/Homer2/vesl-2
  • Opalin
  • p130Cas
  • PLD4
  • very-KIND

ASJC Scopus subject areas

  • Cellular and Molecular Neuroscience
  • Biochemistry

Cite this

Furuichi, T., Shiraishi-Yamaguchi, Y., Sato, A., Sadakata, T., Huang, J., Shinoda, Y., ... Yoshikawa, F. (2011). Systematizing and cloning of genes involved in the cerebellar cortex circuit development. Neurochemical Research, 36(7), 1241-1252. https://doi.org/10.1007/s11064-011-0398-1

Systematizing and cloning of genes involved in the cerebellar cortex circuit development. / Furuichi, Teiichi; Shiraishi-Yamaguchi, Yoko; Sato, Akira; Sadakata, Tetsushi; Huang, Jinhong; Shinoda, Yo; Hayashi, Kanehiro; Mishima, Yuriko; Tomomura, Mineko; Nishibe, Hirozumi; Yoshikawa, Fumio.

In: Neurochemical Research, Vol. 36, No. 7, 07.2011, p. 1241-1252.

Research output: Contribution to journalArticle

Furuichi, T, Shiraishi-Yamaguchi, Y, Sato, A, Sadakata, T, Huang, J, Shinoda, Y, Hayashi, K, Mishima, Y, Tomomura, M, Nishibe, H & Yoshikawa, F 2011, 'Systematizing and cloning of genes involved in the cerebellar cortex circuit development', Neurochemical Research, vol. 36, no. 7, pp. 1241-1252. https://doi.org/10.1007/s11064-011-0398-1
Furuichi T, Shiraishi-Yamaguchi Y, Sato A, Sadakata T, Huang J, Shinoda Y et al. Systematizing and cloning of genes involved in the cerebellar cortex circuit development. Neurochemical Research. 2011 Jul;36(7):1241-1252. https://doi.org/10.1007/s11064-011-0398-1
Furuichi, Teiichi ; Shiraishi-Yamaguchi, Yoko ; Sato, Akira ; Sadakata, Tetsushi ; Huang, Jinhong ; Shinoda, Yo ; Hayashi, Kanehiro ; Mishima, Yuriko ; Tomomura, Mineko ; Nishibe, Hirozumi ; Yoshikawa, Fumio. / Systematizing and cloning of genes involved in the cerebellar cortex circuit development. In: Neurochemical Research. 2011 ; Vol. 36, No. 7. pp. 1241-1252.
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