Systemes analysis of interactions between microRNAs and genes in hepatocellular carcinoma

Yutaka Fukuoka, Motoki Tashiro, Takanori Uchiyama

Research output: Chapter in Book/Report/Conference proceedingConference contribution

1 Citation (Scopus)

Abstract

MicroRNAs (miRNAs) are short noncoding RNAs and can regulate gene expression at the transcriptional and/or translational levels. There is mounting evidence that miRNAs play an important role in the control of the dynamics of localized gene expression. Expression profiling of miRNA in various cancers revealed that miRNA profiles could discriminate malignancies from their counter parts. In this study, to investigate the localized effect of miRNA in cancer, we analyzed gene and miRNA expressions in hepatocellular carcinoma (HCC) and surrounding nontumor tissues. Based on gene expression levels around miRNAs, we investigated how many miRNAs correlated positively/negatively in expression with genes in the vicinity. Next, the Pearson correlation coefficients were compared between the HCC and nontumor tissues. The results imply that the relationship between the intronic miRNAs and their host genes was altered in HCC, and that feedback loops including the host gene, intronic miRNA, target genes might be formed in HCC.

Original languageEnglish
Title of host publication2013 35th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2013
Pages600-603
Number of pages4
DOIs
Publication statusPublished - 2013 Oct 31
Event2013 35th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2013 - Osaka, Japan
Duration: 2013 Jul 32013 Jul 7

Publication series

NameProceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS
ISSN (Print)1557-170X

Other

Other2013 35th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2013
CountryJapan
CityOsaka
Period13/7/313/7/7

ASJC Scopus subject areas

  • Signal Processing
  • Biomedical Engineering
  • Computer Vision and Pattern Recognition
  • Health Informatics

Fingerprint Dive into the research topics of 'Systemes analysis of interactions between microRNAs and genes in hepatocellular carcinoma'. Together they form a unique fingerprint.

  • Cite this

    Fukuoka, Y., Tashiro, M., & Uchiyama, T. (2013). Systemes analysis of interactions between microRNAs and genes in hepatocellular carcinoma. In 2013 35th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2013 (pp. 600-603). [6609571] (Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS). https://doi.org/10.1109/EMBC.2013.6609571