Systemic lupus erythematosus with necrotizing vasculitis and upregulated expression of VLA-4 antigen

T. Takeuchi, K. Aoki, J. Koide, H. Sekine, T. Abe

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We report on a patient (S.A.), with well-defind SLE who developed a perforation of the ileum due to pathologically confirmed necrotizing vasculitis. No anti-DNA antibody was detected at the ileal perforation, and the serum complement level was normal. These findings rais ethe alternative possibility of a cellmediated immune mechanism as a cause of necrotizing vaculitis. Upregulateed expression and function of VLA-4 antigen on peripheral blood T cells were oberved, suggesting that T cells with VLA-4 antigen may participate in the onset and/or perpetuation of vascular inflammation.

Original languageEnglish
Pages (from-to)370-374
Number of pages5
JournalClinical Rheumatology
Issue number3
Publication statusPublished - 1995 May 1



  • Necrotizing Vasculitis
  • Systemic Lups Erythematosus
  • VLA-4 Antigen

ASJC Scopus subject areas

  • Rheumatology

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