Systemic lupus erythematosus with necrotizing vasculitis and upregulated expression of VLA-4 antigen

Tsutomu Takeuchi, K. Aoki, J. Koide, H. Sekine, T. Abe

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

We report on a patient (S.A.), with well-defind SLE who developed a perforation of the ileum due to pathologically confirmed necrotizing vasculitis. No anti-DNA antibody was detected at the ileal perforation, and the serum complement level was normal. These findings rais ethe alternative possibility of a cellmediated immune mechanism as a cause of necrotizing vaculitis. Upregulateed expression and function of VLA-4 antigen on peripheral blood T cells were oberved, suggesting that T cells with VLA-4 antigen may participate in the onset and/or perpetuation of vascular inflammation.

Original languageEnglish
Pages (from-to)370-374
Number of pages5
JournalClinical Rheumatology
Volume14
Issue number3
DOIs
Publication statusPublished - 1995 May
Externally publishedYes

Fingerprint

Integrin alpha4beta1
Vasculitis
Systemic Lupus Erythematosus
T-Lymphocytes
Antigens
Antinuclear Antibodies
Ileum
Blood Vessels
Blood Cells
Inflammation
Serum

Keywords

  • Necrotizing Vasculitis
  • Systemic Lups Erythematosus
  • VLA-4 Antigen

ASJC Scopus subject areas

  • Rheumatology
  • Immunology

Cite this

Systemic lupus erythematosus with necrotizing vasculitis and upregulated expression of VLA-4 antigen. / Takeuchi, Tsutomu; Aoki, K.; Koide, J.; Sekine, H.; Abe, T.

In: Clinical Rheumatology, Vol. 14, No. 3, 05.1995, p. 370-374.

Research output: Contribution to journalArticle

Takeuchi, Tsutomu ; Aoki, K. ; Koide, J. ; Sekine, H. ; Abe, T. / Systemic lupus erythematosus with necrotizing vasculitis and upregulated expression of VLA-4 antigen. In: Clinical Rheumatology. 1995 ; Vol. 14, No. 3. pp. 370-374.
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