Systemically circulating colitogenic memory CD4+ T cells may be an ideal target for the treatment of inflammatory bowel diseases

Takanori Kanai, Mamoru Watanabe, Toshifumi Hibi

Research output: Contribution to journalReview articlepeer-review

5 Citations (Scopus)

Abstract

Inflammatory bowel diseases (IBD) are thought to be caused by a complex interaction of genetic, immunological, and environmental factors. Why is it that once an IBD develops it lasts a long time? Considering this simple question, we propose that coliotogenic memory CD4+T cells that remember the prototype of the disease in each patient are formed in IBD at the onset, and, perceiving them as "benign T-cell leukemia"-like lifelong memory CD4+T cells that hematogenously spread throughout the body, we thus propose that systemic circulating colitogenic memory CD4+T cells would be an ideal target for the treatment of IBD. Accordingly, selective depletion of colitogenic memory CD4+T cells by leukocytapheresis and blockade of circulation of colitogenic memory CD4+T cells by a newly developed immunosuppressant, FTY720, may be associated with dramatic efficacy and a marked reduction of inflammatory cytokines produced by activated leucocytes. We here describe the immunological pathogenesis focusing on the generation of circulating colitogenic memory CD4+T cells and the possible logics of leukocytapheresis and FTY720 for the treatment of IBD.

Original languageEnglish
Pages (from-to)203-209
Number of pages7
JournalKeio Journal of Medicine
Volume58
Issue number4
DOIs
Publication statusPublished - 2009 Dec

Keywords

  • Colitogenic memory CD4 T cells
  • FTY720
  • Inflammatory bowel disease
  • Leukocytapheresis

ASJC Scopus subject areas

  • Medicine(all)

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