T cell receptor gene rearrangement analysis in mycosis fungoides and disseminated lymphocytoma cutis

M. Amagai, K. Hayakawa, N. Amagai, K. Kobayashi, Y. Onodera, N. Shimizu, T. Nishikawa

Research output: Contribution to journalArticlepeer-review

8 Citations (Scopus)

Abstract

A cDNA from the C(T)β2 region of the T cell receptor gene was used as a probe to investigate the clonal composition of T cells in the skin lesions of 3 patients with mycosis fungoides (MF) and 1 patient with disseminated lymphocytoma cutis (DLC). All of these skin lesions showed helper/inducer T cell dominant infiltration. Clonal T cell populations, as evidenced by rearranged DNA bands, were demonstrated in all the skin lesions of the 3 patients with MF, but not in the lesion of the patient with DLC. The patients with MF appeared to have the same gene rearangement pattern in DNA obtained from separate lesions, providing evidence that the T cells in both sites were derived from the same clone. Our results show that this gene rearrangement analysis helps to diagnose difficult cases of lymphoproliferative disorders.

Original languageEnglish
Pages (from-to)193-196
Number of pages4
JournalDermatologica
Volume181
Issue number3
DOIs
Publication statusPublished - 1990

Keywords

  • DNA analysis
  • Disseminated lymphocytoma cutis
  • Mycosis fungoides
  • Rearrangement
  • T cell receptor

ASJC Scopus subject areas

  • Dermatology

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