T-cell recognition of self peptides as tumor rejection antigens

Yutaka Kawakami, Steven A. Rosenberg

Research output: Contribution to journalArticle

49 Citations (Scopus)

Abstract

Human melanoma antigens and their epitopes recognized by T cells have recently been identified. HLA-A2 binding epitopes of melanoma antigens MART-1 and gp100 were characterized and suspected to be subdominant/cryptic self determinants. Together with other findings of tumor-specific mutated self peptides as tumor antigens recognized by T cells, the nature of the antitumor immune response to human melanoma has been revealed at a molecular level. These findings have implications not only for understanding of the immune response to self peptides in normal and pathologic conditions, but also for the development of immunotherapies for cancer and autoimmune diseases.

Original languageEnglish
Pages (from-to)179-190
Number of pages12
JournalImmunologic Research
Volume15
Issue number3
DOIs
Publication statusPublished - 1996 Sep
Externally publishedYes

Fingerprint

Neoplasm Antigens
gp100 Melanoma Antigen
Melanoma-Specific Antigens
T-Lymphocytes
HLA-A2 Antigen
Peptides
T-Lymphocyte Epitopes
Immunotherapy
Autoimmune Diseases
Epitopes
Melanoma
Neoplasms

Keywords

  • Autoimmunity
  • Epitopes, dominance and crypticity
  • Immunotherapy
  • MART-I
  • Melanoma
  • MHC binding motif
  • Self antigens
  • T lymphocytes
  • Tolerance, immunologic
  • Tumor antigens

ASJC Scopus subject areas

  • Immunology

Cite this

T-cell recognition of self peptides as tumor rejection antigens. / Kawakami, Yutaka; Rosenberg, Steven A.

In: Immunologic Research, Vol. 15, No. 3, 09.1996, p. 179-190.

Research output: Contribution to journalArticle

Kawakami, Yutaka ; Rosenberg, Steven A. / T-cell recognition of self peptides as tumor rejection antigens. In: Immunologic Research. 1996 ; Vol. 15, No. 3. pp. 179-190.
@article{5f8f07ed6896410b9e2729aedb76c28c,
title = "T-cell recognition of self peptides as tumor rejection antigens",
abstract = "Human melanoma antigens and their epitopes recognized by T cells have recently been identified. HLA-A2 binding epitopes of melanoma antigens MART-1 and gp100 were characterized and suspected to be subdominant/cryptic self determinants. Together with other findings of tumor-specific mutated self peptides as tumor antigens recognized by T cells, the nature of the antitumor immune response to human melanoma has been revealed at a molecular level. These findings have implications not only for understanding of the immune response to self peptides in normal and pathologic conditions, but also for the development of immunotherapies for cancer and autoimmune diseases.",
keywords = "Autoimmunity, Epitopes, dominance and crypticity, Immunotherapy, MART-I, Melanoma, MHC binding motif, Self antigens, T lymphocytes, Tolerance, immunologic, Tumor antigens",
author = "Yutaka Kawakami and Rosenberg, {Steven A.}",
year = "1996",
month = "9",
doi = "10.1007/BF02918248",
language = "English",
volume = "15",
pages = "179--190",
journal = "Immunologic Research",
issn = "0257-277X",
publisher = "Humana Press",
number = "3",

}

TY - JOUR

T1 - T-cell recognition of self peptides as tumor rejection antigens

AU - Kawakami, Yutaka

AU - Rosenberg, Steven A.

PY - 1996/9

Y1 - 1996/9

N2 - Human melanoma antigens and their epitopes recognized by T cells have recently been identified. HLA-A2 binding epitopes of melanoma antigens MART-1 and gp100 were characterized and suspected to be subdominant/cryptic self determinants. Together with other findings of tumor-specific mutated self peptides as tumor antigens recognized by T cells, the nature of the antitumor immune response to human melanoma has been revealed at a molecular level. These findings have implications not only for understanding of the immune response to self peptides in normal and pathologic conditions, but also for the development of immunotherapies for cancer and autoimmune diseases.

AB - Human melanoma antigens and their epitopes recognized by T cells have recently been identified. HLA-A2 binding epitopes of melanoma antigens MART-1 and gp100 were characterized and suspected to be subdominant/cryptic self determinants. Together with other findings of tumor-specific mutated self peptides as tumor antigens recognized by T cells, the nature of the antitumor immune response to human melanoma has been revealed at a molecular level. These findings have implications not only for understanding of the immune response to self peptides in normal and pathologic conditions, but also for the development of immunotherapies for cancer and autoimmune diseases.

KW - Autoimmunity

KW - Epitopes, dominance and crypticity

KW - Immunotherapy

KW - MART-I

KW - Melanoma

KW - MHC binding motif

KW - Self antigens

KW - T lymphocytes

KW - Tolerance, immunologic

KW - Tumor antigens

UR - http://www.scopus.com/inward/record.url?scp=0029784505&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0029784505&partnerID=8YFLogxK

U2 - 10.1007/BF02918248

DO - 10.1007/BF02918248

M3 - Article

C2 - 8902575

AN - SCOPUS:0029784505

VL - 15

SP - 179

EP - 190

JO - Immunologic Research

JF - Immunologic Research

SN - 0257-277X

IS - 3

ER -