T280M and V249I polymorphisms of fractalkine receptor CX3CR1 and ischemic cerebrovascular disease

Hidenori Hattori, Daisuke Ito, Norio Tanahashi, Mitsuru Murata, Ikuo Saito, Kiyoaki Watanabe, Norihiro Suzuki

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

The contribution to atherosclerosis of two CX3CR1 single nucleotide polymorphisms, V249I and T280M has been recently reported. The atherosclerosis of intracranial vessels is thought to be the major pathological mechanism of ischemic stroke. In this study, we investigated the risk of ischemic stroke associated with fractalkine receptor CX3CR1 polymorphisms. We investigated the T280M and V249I mutations in the CX3CR1 gene in 235 Japanese patients with ischemic cerebrovascular disease (CVD) and 306 age- and sex-matched healthy controls. Polymerase chain reaction and restriction fragment length polymorphism were used for genotyping. There was no significant difference in both polymorphisms between patients with ischemic CVD and controls (VV versus II + VI, p = 0.83; TT versus MM + TM, p = 0.66). The I and M allele frequencies were not significantly different between CVD patients and controls: odds ratio (OR) = 0.89 (95% confidence interval (CI) = 0.50-1.60, p = 0.70) and OR = 1.19 (95% CI = 0.71-2.00, p = 0.51), respectively. We found eight of nine possible combined genotypes, including a new haplotype V249-M280, in Japanese. Our results show that these CX3CR1 gene polymorphisms are not associated with an increased risk for ischemic CVD in the Japanese population.

Original languageEnglish
Pages (from-to)132-135
Number of pages4
JournalNeuroscience Letters
Volume374
Issue number2
DOIs
Publication statusPublished - 2005 Feb 10

Keywords

  • Atherosclerosis
  • CX3CR1
  • Fractalkine
  • Ischemic stroke
  • Polymorphism

ASJC Scopus subject areas

  • Neuroscience(all)

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