TAB1

An activator of the TAK1 MAPKKK in TGF-β signal transduction

Hiroshi Shibuya, Kyoko Yamaguchi, Kyoko Shirakabe, Akane Tonegawa, Yukiko Gotoh, Naoto Ueno, Kenji Irie, Eisuke Nishida, Kunihiro Matsumoto

Research output: Contribution to journalArticle

475 Citations (Scopus)

Abstract

Transforming growth factor-β (TGF-β) regulates many aspects of cellular function. A member of the mitogen-activated protein kinase kinase kinase (MAPKKK) family, TAK1, was previously identified as a mediator in the signaling pathway of TGF-β superfamily members. The yeast two-hybrid system has now revealed two human proteins, termed TAB1 and TAB2 (for TAK1 binding protein), that interact with TAK1. TAB1 and TAK1 were co-immunoprecipitated from mammalian cells. Overproduction of TAB1 enhanced activity of the plasminogen activator inhibitor 1 gene promoter, which is regulated by TGF-β, and increased the kinase activity of TAK1. TAB1 may function as an activator of the TAK1 MAPKKK in TGF-β signal transduction.

Original languageEnglish
Pages (from-to)1179-1182
Number of pages4
JournalScience
Volume272
Issue number5265
Publication statusPublished - 1996 May 24

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MAP Kinase Kinase Kinases
Transforming Growth Factors
Signal Transduction
Activator Appliances
Two-Hybrid System Techniques
Plasminogen Activator Inhibitor 1
Carrier Proteins
Phosphotransferases
Genes

ASJC Scopus subject areas

  • General

Cite this

Shibuya, H., Yamaguchi, K., Shirakabe, K., Tonegawa, A., Gotoh, Y., Ueno, N., ... Matsumoto, K. (1996). TAB1: An activator of the TAK1 MAPKKK in TGF-β signal transduction. Science, 272(5265), 1179-1182.

TAB1 : An activator of the TAK1 MAPKKK in TGF-β signal transduction. / Shibuya, Hiroshi; Yamaguchi, Kyoko; Shirakabe, Kyoko; Tonegawa, Akane; Gotoh, Yukiko; Ueno, Naoto; Irie, Kenji; Nishida, Eisuke; Matsumoto, Kunihiro.

In: Science, Vol. 272, No. 5265, 24.05.1996, p. 1179-1182.

Research output: Contribution to journalArticle

Shibuya, H, Yamaguchi, K, Shirakabe, K, Tonegawa, A, Gotoh, Y, Ueno, N, Irie, K, Nishida, E & Matsumoto, K 1996, 'TAB1: An activator of the TAK1 MAPKKK in TGF-β signal transduction', Science, vol. 272, no. 5265, pp. 1179-1182.
Shibuya H, Yamaguchi K, Shirakabe K, Tonegawa A, Gotoh Y, Ueno N et al. TAB1: An activator of the TAK1 MAPKKK in TGF-β signal transduction. Science. 1996 May 24;272(5265):1179-1182.
Shibuya, Hiroshi ; Yamaguchi, Kyoko ; Shirakabe, Kyoko ; Tonegawa, Akane ; Gotoh, Yukiko ; Ueno, Naoto ; Irie, Kenji ; Nishida, Eisuke ; Matsumoto, Kunihiro. / TAB1 : An activator of the TAK1 MAPKKK in TGF-β signal transduction. In: Science. 1996 ; Vol. 272, No. 5265. pp. 1179-1182.
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