TAK1 Prevents Endothelial Apoptosis and Maintains Vascular Integrity

Hisamichi Naito, Tomohiro Iba, Taku Wakabayashi, Ikue Tai-Nagara, Jun ichi Suehiro, Weizhen Jia, Daisuke Eino, Susumu Sakimoto, Fumitaka Muramatsu, Hiroyasu Kidoya, Hiroyuki Sakurai, Takashi Satoh, Shizuo Akira, Yoshiaki Kubota, Nobuyuki Takakura

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Mechanisms by which endothelial cells (ECs) maintain themselves in inflammatory microenvironments remain unclear. Naito et al. show that TAK1 prevents EC apoptosis induced by TNF-α-expressing myeloid cells. TAK1 protects ECs and ensures the maintenance of vascular integrity and homeostasis under inflammatory conditions.

Original languageEnglish
Pages (from-to)151-166.e7
JournalDevelopmental Cell
Volume48
Issue number2
DOIs
Publication statusPublished - 2019 Jan 28

Fingerprint

Endothelial cells
Blood Vessels
Endothelial Cells
Apoptosis
Myeloid Cells
Homeostasis
Maintenance

Keywords

  • apoptosis
  • inflammation
  • intestinal microbiota
  • TAK1
  • TNF-α
  • tumor angiogenesis
  • vascular homeostasis

ASJC Scopus subject areas

  • Molecular Biology
  • Biochemistry, Genetics and Molecular Biology(all)
  • Developmental Biology
  • Cell Biology

Cite this

Naito, H., Iba, T., Wakabayashi, T., Tai-Nagara, I., Suehiro, J. I., Jia, W., ... Takakura, N. (2019). TAK1 Prevents Endothelial Apoptosis and Maintains Vascular Integrity. Developmental Cell, 48(2), 151-166.e7. https://doi.org/10.1016/j.devcel.2018.12.002

TAK1 Prevents Endothelial Apoptosis and Maintains Vascular Integrity. / Naito, Hisamichi; Iba, Tomohiro; Wakabayashi, Taku; Tai-Nagara, Ikue; Suehiro, Jun ichi; Jia, Weizhen; Eino, Daisuke; Sakimoto, Susumu; Muramatsu, Fumitaka; Kidoya, Hiroyasu; Sakurai, Hiroyuki; Satoh, Takashi; Akira, Shizuo; Kubota, Yoshiaki; Takakura, Nobuyuki.

In: Developmental Cell, Vol. 48, No. 2, 28.01.2019, p. 151-166.e7.

Research output: Contribution to journalArticle

Naito, H, Iba, T, Wakabayashi, T, Tai-Nagara, I, Suehiro, JI, Jia, W, Eino, D, Sakimoto, S, Muramatsu, F, Kidoya, H, Sakurai, H, Satoh, T, Akira, S, Kubota, Y & Takakura, N 2019, 'TAK1 Prevents Endothelial Apoptosis and Maintains Vascular Integrity', Developmental Cell, vol. 48, no. 2, pp. 151-166.e7. https://doi.org/10.1016/j.devcel.2018.12.002
Naito H, Iba T, Wakabayashi T, Tai-Nagara I, Suehiro JI, Jia W et al. TAK1 Prevents Endothelial Apoptosis and Maintains Vascular Integrity. Developmental Cell. 2019 Jan 28;48(2):151-166.e7. https://doi.org/10.1016/j.devcel.2018.12.002
Naito, Hisamichi ; Iba, Tomohiro ; Wakabayashi, Taku ; Tai-Nagara, Ikue ; Suehiro, Jun ichi ; Jia, Weizhen ; Eino, Daisuke ; Sakimoto, Susumu ; Muramatsu, Fumitaka ; Kidoya, Hiroyasu ; Sakurai, Hiroyuki ; Satoh, Takashi ; Akira, Shizuo ; Kubota, Yoshiaki ; Takakura, Nobuyuki. / TAK1 Prevents Endothelial Apoptosis and Maintains Vascular Integrity. In: Developmental Cell. 2019 ; Vol. 48, No. 2. pp. 151-166.e7.
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