TAK1 Prevents Endothelial Apoptosis and Maintains Vascular Integrity

Hisamichi Naito, Tomohiro Iba, Taku Wakabayashi, Ikue Tai-Nagara, Jun ichi Suehiro, Weizhen Jia, Daisuke Eino, Susumu Sakimoto, Fumitaka Muramatsu, Hiroyasu Kidoya, Hiroyuki Sakurai, Takashi Satoh, Shizuo Akira, Yoshiaki Kubota, Nobuyuki Takakura

Research output: Contribution to journalArticlepeer-review

5 Citations (Scopus)

Abstract

Mechanisms by which endothelial cells (ECs) maintain themselves in inflammatory microenvironments remain unclear. Naito et al. show that TAK1 prevents EC apoptosis induced by TNF-α-expressing myeloid cells. TAK1 protects ECs and ensures the maintenance of vascular integrity and homeostasis under inflammatory conditions.

Original languageEnglish
Pages (from-to)151-166.e7
JournalDevelopmental Cell
Volume48
Issue number2
DOIs
Publication statusPublished - 2019 Jan 28

Keywords

  • TAK1
  • TNF-α
  • apoptosis
  • inflammation
  • intestinal microbiota
  • tumor angiogenesis
  • vascular homeostasis

ASJC Scopus subject areas

  • Molecular Biology
  • Biochemistry, Genetics and Molecular Biology(all)
  • Developmental Biology
  • Cell Biology

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