Target protein-oriented isolations for chemical biology based on natural products

Midori A. Arai, Masami Ishibashi

Research output: Contribution to journalReview articlepeer-review


Natural products have contributed to development of medicine for a long time. The structures and bioactivities of natural products often exceed the human knowledge and imagination. We have developed target protein-oriented natural products isolation methods to quick find bioactive compounds from natural resources(compounds mixture). This review summarizes our recent results including protein beads methods and protein plate method for neural stem cells differentiation differentiation activators and and /or new showed cancer cytotoxicity drug candidates. against Isolated cancer compounds cells. Syntheses accelerated of isolated neural compounds stem cells were also described. As protein binding ability tightly related bioactivity, protein based natural products isolation would be a powerful way to find new candidate of medicines.

Original languageEnglish
Pages (from-to)684-693
Number of pages10
JournalYuki Gosei Kagaku Kyokaishi/Journal of Synthetic Organic Chemistry
Issue number7
Publication statusPublished - 2021 Jul 1


  • Cancer cells
  • Natural products
  • Neural stem cells
  • Protein beads
  • Protein plates

ASJC Scopus subject areas

  • Organic Chemistry


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