Target protein-oriented isolations for chemical biology based on natural products

Natural products have contributed to development of medicine for a long time. The structures and bioactivities of natural products often exceed the human knowledge and imagination. We have developed target protein-oriented natural products isolation methods to quick find bioactive compounds from natural resources(compounds mixture). This review summarizes our recent results including protein beads methods and protein plate method for neural stem cells differenti^ation differentiation ^activators and ^and ／or ^new showed ^cancer cytotoxicity ^{drug candidates.} against ^Isolated cancer ^compounds cells. Syntheses ^accelerated of isolated ^neural compounds ^stem cells were also described. As protein binding ability tightly related bioactivity, protein based natural products isolation would be a powerful way to find new candidate of medicines.