Target-selective degradation of cancer-related proteins by novel photosensitizers for molecular-targeted photodynamic therapy

Kazunobu Toshima, Shuho Tanimoto, Kana Tsumura, Kazuo Umezawa, Daisuke Takahashi

Research output: Contribution to journalReview article

3 Citations (Scopus)

Abstract

Proteins are key players in many biological events including cancers. The development of novel photosensitizers for the selective degradation of cancer-related proteins has attracted much attention in the fields of photodynamic therapy for various cancers. In this review article, several novel photosensitizers, which selectively degrade cancer-related proteins under photoirradiation and mild conditions without any further additives, are introduced. This novel class of photosensitizers promises bright prospects for finding molecular-targeted drugs for cancer photodynamic therapy in the near future.

Original languageEnglish
Pages (from-to)1581-1584
Number of pages4
JournalCancer science
Volume100
Issue number9
DOIs
Publication statusPublished - 2009 Sep 1

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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