Target-selective degradation of proteins and oligosaccharides by light-activated hybrid molecules for molecular-targeted photodynamic therapy

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Abstract

Proteins and oligosaccharides are key players in many biological events. The development of novel methods for the selective degradation of targeted proteins and oligosaccharides has attracted much attention in the fields of chemistry, biology and medicine. Target-selective degradations of proteins, such as estrogen receptor-α androgen receptor and HIV-1 protease, by light-activated 2-phenylquinoline-steroid hormone hybrids, porphyrin derivatives and fullerene-sugar hybrids, and target-selective degradation of oligosaccharides, such as a T-antigen disaccharide, by a light-activated anthraquinone-lectin hybrid have been achieved. This novel class of light-activated and molecular-targeted molecules, namely molecular-targeted photosensitizers, promise bright prospects for finding not only molecular-targeted bioprobes for future application in the life sciences but also molecular-targeted drugs for future photodynamic therapy.

Original languageEnglish
Pages (from-to)1113-1124
Number of pages12
JournalFuture Medicinal Chemistry
Volume1
Issue number6
DOIs
Publication statusPublished - 2009 Sep

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Molecular Targeted Therapy
Photochemotherapy
Oligosaccharides
Proteolysis
Light
Fullerenes
Anthraquinones
Photosensitizing Agents
Biological Science Disciplines
Disaccharides
Viral Tumor Antigens
Porphyrins
Androgen Receptors
Biosensing Techniques
Lectins
Estrogen Receptors
Steroids
Medicine
Hormones
Pharmaceutical Preparations

ASJC Scopus subject areas

  • Drug Discovery
  • Pharmacology
  • Molecular Medicine

Cite this

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abstract = "Proteins and oligosaccharides are key players in many biological events. The development of novel methods for the selective degradation of targeted proteins and oligosaccharides has attracted much attention in the fields of chemistry, biology and medicine. Target-selective degradations of proteins, such as estrogen receptor-α androgen receptor and HIV-1 protease, by light-activated 2-phenylquinoline-steroid hormone hybrids, porphyrin derivatives and fullerene-sugar hybrids, and target-selective degradation of oligosaccharides, such as a T-antigen disaccharide, by a light-activated anthraquinone-lectin hybrid have been achieved. This novel class of light-activated and molecular-targeted molecules, namely molecular-targeted photosensitizers, promise bright prospects for finding not only molecular-targeted bioprobes for future application in the life sciences but also molecular-targeted drugs for future photodynamic therapy.",
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