Target-selective degradation of proteins by a light-activated 2-phenylquinoline-estradiol hybrid

Akane Suzuki, Kana Tsumura, Takeo Tsuzuki, Shuichi Matsumura, Kazunobu Toshima

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

A designed 2-phenylquinoline-estradiol hybrid effectively and selectively degraded the target transcription factor, human estrogen receptor-α (hER-α), which has a high affinity with the estradiol moiety, under long-wavelength UV photo-irradiation, without additives and under neutral conditions.

Original languageEnglish
Pages (from-to)4260-4262
Number of pages3
JournalChemical Communications
Issue number41
DOIs
Publication statusPublished - 2007

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Transcription factors
Estradiol
Irradiation
Proteins
Degradation
Wavelength
Estrogen Receptors
Transcription Factors
Estrogens
2-phenylquinoline

ASJC Scopus subject areas

  • Chemistry(all)

Cite this

Target-selective degradation of proteins by a light-activated 2-phenylquinoline-estradiol hybrid. / Suzuki, Akane; Tsumura, Kana; Tsuzuki, Takeo; Matsumura, Shuichi; Toshima, Kazunobu.

In: Chemical Communications, No. 41, 2007, p. 4260-4262.

Research output: Contribution to journalArticle

Suzuki, Akane ; Tsumura, Kana ; Tsuzuki, Takeo ; Matsumura, Shuichi ; Toshima, Kazunobu. / Target-selective degradation of proteins by a light-activated 2-phenylquinoline-estradiol hybrid. In: Chemical Communications. 2007 ; No. 41. pp. 4260-4262.
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