Target-selective degradation of proteins by a light-activated 2-phenylquinoline-estradiol hybrid

Akane Suzuki, Kana Tsumura, Takeo Tsuzuki, Shuichi Matsumura, Kazunobu Toshima

Research output: Contribution to journalArticle

14 Citations (Scopus)


A designed 2-phenylquinoline-estradiol hybrid effectively and selectively degraded the target transcription factor, human estrogen receptor-α (hER-α), which has a high affinity with the estradiol moiety, under long-wavelength UV photo-irradiation, without additives and under neutral conditions.

Original languageEnglish
Pages (from-to)4260-4262
Number of pages3
JournalChemical Communications
Issue number41
Publication statusPublished - 2007 Oct 24


ASJC Scopus subject areas

  • Catalysis
  • Electronic, Optical and Magnetic Materials
  • Ceramics and Composites
  • Chemistry(all)
  • Surfaces, Coatings and Films
  • Metals and Alloys
  • Materials Chemistry

Cite this