Target-Selective Fluorescence Imaging and Photocytotoxicity against H2O2 High-Expressing Cancer Cells Using a Photoactivatable Theranostic Agent

Ryoma Takagi, Ayano Takeda, Daisuke Takahashi, Kazunobu Toshima

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

A purpose-designed and synthesized H2O2-reactive and photoactivatable theranostic agent 1 consisting of 1) an arylboronic acid moiety, 2) pro-fluorophore moiety, and 3) photoactivatable moiety (photosensitizer), selectively and effectively reacted with H2O2 while simultaneously releasing resorufin for fluorescence detection under neutral aqueous conditions. In addition, 1 was cell-permeable, and exhibited effective photocytotoxicity against fluorescently visualized cells only upon photoirradiation. The results also showed that 1 produced a selective fluorescence response to H2O2, even in living cultured cells.

Original languageEnglish
Pages (from-to)2656-2659
Number of pages4
JournalChemistry - An Asian Journal
Volume12
Issue number20
DOIs
Publication statusPublished - 2017 Oct 18

Keywords

  • cytotoxicity
  • fluorescent probes
  • peroxides
  • sensitizers
  • theranostics

ASJC Scopus subject areas

  • Biochemistry
  • Organic Chemistry

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