A purpose-designed and synthesized H2O2-reactive and photoactivatable theranostic agent 1 consisting of 1) an arylboronic acid moiety, 2) pro-fluorophore moiety, and 3) photoactivatable moiety (photosensitizer), selectively and effectively reacted with H2O2 while simultaneously releasing resorufin for fluorescence detection under neutral aqueous conditions. In addition, 1 was cell-permeable, and exhibited effective photocytotoxicity against fluorescently visualized cells only upon photoirradiation. The results also showed that 1 produced a selective fluorescence response to H2O2, even in living cultured cells.
|Number of pages||4|
|Journal||Chemistry - An Asian Journal|
|Publication status||Published - 2017 Oct 18|
- fluorescent probes
ASJC Scopus subject areas
- Organic Chemistry