A purpose-designed anthraquinone-monoclonal antibody (anti-sialyl Lewis A (sLea) mAb) hybrid 6 selectively bound to and effectively degraded the target glycoprotein, HSA (human serum albumin)-sLea conjugate 4. Degradation was achieved using long wavelength UV light irradiation in the absence of any additives and under neutral conditions. Furthermore, the hybrid 6 exhibited selective photo-cytotoxicity against the sLea positive cancer cells A431 and WiDr cells only upon photo-irradiation.
ASJC Scopus subject areas
- Pharmaceutical Science