Target-selective photo-degradation of AFP-L3 and selective photo-cytotoxicity against HuH-7 hepatocarcinoma cells using an anthraquinone-PhoSL hybrid

Mai Okuyama, Haruna Ueno, Yuka Kobayashi, Hirokazu Kawagishi, Daisuke Takahashi, Kazunobu Toshima

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

A purposefully-designed anthraquinone-Pholiota squarrosa lectin (PhoSL) hybrid effectively degraded α-fetoprotein-L3 (AFP-L3) associated with liver cancer. Degradation was achieved under light irradiation in the absence of any additives and under neutral pH conditions. Moreover, the hybrid effectively exhibited selective photo-cytotoxicity against HuH-7 hepatocarcinoma cells upon photo-irradiation.

Original languageEnglish
Pages (from-to)2169-2172
Number of pages4
JournalChemical Communications
Volume52
Issue number10
DOIs
Publication statusPublished - 2016

Fingerprint

Anthraquinones
Photodegradation
Cytotoxicity
Lectins
Irradiation
Fetal Proteins
Liver
Degradation

ASJC Scopus subject areas

  • Chemistry(all)
  • Catalysis
  • Ceramics and Composites
  • Electronic, Optical and Magnetic Materials
  • Surfaces, Coatings and Films
  • Materials Chemistry
  • Metals and Alloys

Cite this

Target-selective photo-degradation of AFP-L3 and selective photo-cytotoxicity against HuH-7 hepatocarcinoma cells using an anthraquinone-PhoSL hybrid. / Okuyama, Mai; Ueno, Haruna; Kobayashi, Yuka; Kawagishi, Hirokazu; Takahashi, Daisuke; Toshima, Kazunobu.

In: Chemical Communications, Vol. 52, No. 10, 2016, p. 2169-2172.

Research output: Contribution to journalArticle

@article{122003a5c3bd4710849e0f41ec827ae3,
title = "Target-selective photo-degradation of AFP-L3 and selective photo-cytotoxicity against HuH-7 hepatocarcinoma cells using an anthraquinone-PhoSL hybrid",
abstract = "A purposefully-designed anthraquinone-Pholiota squarrosa lectin (PhoSL) hybrid effectively degraded α-fetoprotein-L3 (AFP-L3) associated with liver cancer. Degradation was achieved under light irradiation in the absence of any additives and under neutral pH conditions. Moreover, the hybrid effectively exhibited selective photo-cytotoxicity against HuH-7 hepatocarcinoma cells upon photo-irradiation.",
author = "Mai Okuyama and Haruna Ueno and Yuka Kobayashi and Hirokazu Kawagishi and Daisuke Takahashi and Kazunobu Toshima",
year = "2016",
doi = "10.1039/c5cc09542e",
language = "English",
volume = "52",
pages = "2169--2172",
journal = "Chemical Communications",
issn = "1359-7345",
publisher = "Royal Society of Chemistry",
number = "10",

}

TY - JOUR

T1 - Target-selective photo-degradation of AFP-L3 and selective photo-cytotoxicity against HuH-7 hepatocarcinoma cells using an anthraquinone-PhoSL hybrid

AU - Okuyama, Mai

AU - Ueno, Haruna

AU - Kobayashi, Yuka

AU - Kawagishi, Hirokazu

AU - Takahashi, Daisuke

AU - Toshima, Kazunobu

PY - 2016

Y1 - 2016

N2 - A purposefully-designed anthraquinone-Pholiota squarrosa lectin (PhoSL) hybrid effectively degraded α-fetoprotein-L3 (AFP-L3) associated with liver cancer. Degradation was achieved under light irradiation in the absence of any additives and under neutral pH conditions. Moreover, the hybrid effectively exhibited selective photo-cytotoxicity against HuH-7 hepatocarcinoma cells upon photo-irradiation.

AB - A purposefully-designed anthraquinone-Pholiota squarrosa lectin (PhoSL) hybrid effectively degraded α-fetoprotein-L3 (AFP-L3) associated with liver cancer. Degradation was achieved under light irradiation in the absence of any additives and under neutral pH conditions. Moreover, the hybrid effectively exhibited selective photo-cytotoxicity against HuH-7 hepatocarcinoma cells upon photo-irradiation.

UR - http://www.scopus.com/inward/record.url?scp=84956655949&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84956655949&partnerID=8YFLogxK

U2 - 10.1039/c5cc09542e

DO - 10.1039/c5cc09542e

M3 - Article

C2 - 26698630

AN - SCOPUS:84956655949

VL - 52

SP - 2169

EP - 2172

JO - Chemical Communications

JF - Chemical Communications

SN - 1359-7345

IS - 10

ER -