Target-selective photo-degradation of HIV-1 protease by a fullerene-sugar hybrid

Shuho Tanimoto, Satoshi Sakai, Shuichi Matsumura, Daisuke Takahashi, Kazunobu Toshima

Research output: Contribution to journalArticle

49 Citations (Scopus)

Abstract

A designed fullerene-sugar hybrid effectively and selectively degraded the target protein, HIV-1 protease, which has high affinity for the fullerene moiety; degradation was achieved using long-wavelength UV or visible photo-irradiation, in the absence of any additives and under neutral conditions.

Original languageEnglish
Pages (from-to)5767-5769
Number of pages3
JournalChemical Communications
Issue number44
DOIs
Publication statusPublished - 2008

ASJC Scopus subject areas

  • Catalysis
  • Electronic, Optical and Magnetic Materials
  • Ceramics and Composites
  • Chemistry(all)
  • Surfaces, Coatings and Films
  • Metals and Alloys
  • Materials Chemistry

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