Target-selective photo-degradation of verotoxin-1 and reduction of its cytotoxicity to Vero cells using porphyrin-globotriose hybrids

Atsushi Okochi, Shuho Tanimoto, Daisuke Takahashi, Kazunobu Toshima

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Designed and synthesized porphyrin-globotriose hybrids effectively degraded verotoxin-1, which causes severe bloody diarrhoea and fetal hemolytic uremic syndrome (HUS). Degradation was achieved using long-wavelength UV or visible light irradiation in the absence of any additives and under neutral conditions. Moreover, the hybrids neutralized the cytotoxicity of verotoxin upon photo-irradiation.

Original languageEnglish
Pages (from-to)6027-6029
Number of pages3
JournalChemical Communications
Volume49
Issue number54
DOIs
Publication statusPublished - 2013 Jul 11

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Shiga Toxins
Porphyrins
Photodegradation
Cytotoxicity
Irradiation
Degradation
Wavelength
globotriose

ASJC Scopus subject areas

  • Metals and Alloys
  • Materials Chemistry
  • Surfaces, Coatings and Films
  • Electronic, Optical and Magnetic Materials
  • Ceramics and Composites
  • Catalysis
  • Chemistry(all)

Cite this

Target-selective photo-degradation of verotoxin-1 and reduction of its cytotoxicity to Vero cells using porphyrin-globotriose hybrids. / Okochi, Atsushi; Tanimoto, Shuho; Takahashi, Daisuke; Toshima, Kazunobu.

In: Chemical Communications, Vol. 49, No. 54, 11.07.2013, p. 6027-6029.

Research output: Contribution to journalArticle

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