Target-selective photodegradation of HIV-1 protease and inhibition of HIV-1 replication in living cells by designed fullerene-sugar hybrids

Shuho Tanimoto, Satoshi Sakai, Eriko Kudo, Seiji Okada, Shuichi Matsumura, Daisuke Takahashi, Kazunobu Toshima

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

Sweet degradation: A designed fullerene-sugar hybrid selectively caused the degradation of HIV-1 protease, an important target of anti-HIV therapy. Degradation was achieved at irradiation with long-wavelength UV (365 nm) or visible light (diffuse sunlight) in the absence of any additives and under neutral conditions. Moreover, the hybrid inhibited HIV-1 replication in living cells infected with HIV-1.

Original languageEnglish
Pages (from-to)911-914
Number of pages4
JournalChemistry - An Asian Journal
Volume7
Issue number5
DOIs
Publication statusPublished - 2012 May

Fingerprint

Fullerenes
Photolysis
Photodegradation
Sugars
HIV-1
Cells
Degradation
Sunlight
HIV
Light
Irradiation
Wavelength
Human immunodeficiency virus 1 p16 protease
Therapeutics

Keywords

  • antiviral agents
  • fullerenes
  • inhibitors
  • photolysis
  • proteins

ASJC Scopus subject areas

  • Chemistry(all)
  • Medicine(all)

Cite this

Target-selective photodegradation of HIV-1 protease and inhibition of HIV-1 replication in living cells by designed fullerene-sugar hybrids. / Tanimoto, Shuho; Sakai, Satoshi; Kudo, Eriko; Okada, Seiji; Matsumura, Shuichi; Takahashi, Daisuke; Toshima, Kazunobu.

In: Chemistry - An Asian Journal, Vol. 7, No. 5, 05.2012, p. 911-914.

Research output: Contribution to journalArticle

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