Abstract
Sweet degradation: A designed fullerene-sugar hybrid selectively caused the degradation of HIV-1 protease, an important target of anti-HIV therapy. Degradation was achieved at irradiation with long-wavelength UV (365 nm) or visible light (diffuse sunlight) in the absence of any additives and under neutral conditions. Moreover, the hybrid inhibited HIV-1 replication in living cells infected with HIV-1.
Original language | English |
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Pages (from-to) | 911-914 |
Number of pages | 4 |
Journal | Chemistry - An Asian Journal |
Volume | 7 |
Issue number | 5 |
DOIs | |
Publication status | Published - 2012 May |
Keywords
- antiviral agents
- fullerenes
- inhibitors
- photolysis
- proteins
ASJC Scopus subject areas
- Biochemistry
- Organic Chemistry