Abstract
Sweet degradation: A designed fullerene-sugar hybrid selectively caused the degradation of HIV-1 protease, an important target of anti-HIV therapy. Degradation was achieved at irradiation with long-wavelength UV (365 nm) or visible light (diffuse sunlight) in the absence of any additives and under neutral conditions. Moreover, the hybrid inhibited HIV-1 replication in living cells infected with HIV-1.
| Original language | English |
|---|---|
| Pages (from-to) | 911-914 |
| Number of pages | 4 |
| Journal | Chemistry - An Asian Journal |
| Volume | 7 |
| Issue number | 5 |
| DOIs | |
| Publication status | Published - 2012 May 1 |
Keywords
- antiviral agents
- fullerenes
- inhibitors
- photolysis
- proteins
ASJC Scopus subject areas
- Biochemistry
- Organic Chemistry
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Cite this
Tanimoto, S., Sakai, S., Kudo, E., Okada, S., Matsumura, S., Takahashi, D., & Toshima, K. (2012). Target-selective photodegradation of HIV-1 protease and inhibition of HIV-1 replication in living cells by designed fullerene-sugar hybrids. Chemistry - An Asian Journal, 7(5), 911-914. https://doi.org/10.1002/asia.201101043