Target-selective photodegradation of HIV-1 protease and inhibition of HIV-1 replication in living cells by designed fullerene-sugar hybrids

Shuho Tanimoto, Satoshi Sakai, Eriko Kudo, Seiji Okada, Shuichi Matsumura, Daisuke Takahashi, Kazunobu Toshima

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

Sweet degradation: A designed fullerene-sugar hybrid selectively caused the degradation of HIV-1 protease, an important target of anti-HIV therapy. Degradation was achieved at irradiation with long-wavelength UV (365 nm) or visible light (diffuse sunlight) in the absence of any additives and under neutral conditions. Moreover, the hybrid inhibited HIV-1 replication in living cells infected with HIV-1.

Original languageEnglish
Pages (from-to)911-914
Number of pages4
JournalChemistry - An Asian Journal
Volume7
Issue number5
DOIs
Publication statusPublished - 2012 May 1

Keywords

  • antiviral agents
  • fullerenes
  • inhibitors
  • photolysis
  • proteins

ASJC Scopus subject areas

  • Biochemistry
  • Organic Chemistry

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