Target-selective photodegradation of HIV-1 protease and inhibition of HIV-1 replication in living cells by designed fullerene-sugar hybrids

Shuho Tanimoto; Satoshi Sakai; Eriko Kudo; Seiji Okada; Shuichi Matsumura; Daisuke Takahashi; Kazunobu Toshima

doi:10.1002/asia.201101043

Target-selective photodegradation of HIV-1 protease and inhibition of HIV-1 replication in living cells by designed fullerene-sugar hybrids

Shuho Tanimoto, Satoshi Sakai, Eriko Kudo, Seiji Okada, Shuichi Matsumura, Daisuke Takahashi, Kazunobu Toshima

Department of Applied Chemistry

Research output: Contribution to journal › Article › peer-review

23 Citations (Scopus)

Abstract

Sweet degradation: A designed fullerene-sugar hybrid selectively caused the degradation of HIV-1 protease, an important target of anti-HIV therapy. Degradation was achieved at irradiation with long-wavelength UV (365 nm) or visible light (diffuse sunlight) in the absence of any additives and under neutral conditions. Moreover, the hybrid inhibited HIV-1 replication in living cells infected with HIV-1.

Original language	English
Pages (from-to)	911-914
Number of pages	4
Journal	Chemistry - An Asian Journal
Volume	7
Issue number	5
DOIs	https://doi.org/10.1002/asia.201101043
Publication status	Published - 2012 May

Keywords

antiviral agents
fullerenes
inhibitors
photolysis
proteins

ASJC Scopus subject areas

Biochemistry
Organic Chemistry

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1002/asia.201101043

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abstract = "Sweet degradation: A designed fullerene-sugar hybrid selectively caused the degradation of HIV-1 protease, an important target of anti-HIV therapy. Degradation was achieved at irradiation with long-wavelength UV (365 nm) or visible light (diffuse sunlight) in the absence of any additives and under neutral conditions. Moreover, the hybrid inhibited HIV-1 replication in living cells infected with HIV-1.",

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AU - Tanimoto, Shuho

AU - Sakai, Satoshi

AU - Kudo, Eriko

AU - Okada, Seiji

AU - Matsumura, Shuichi

AU - Takahashi, Daisuke

AU - Toshima, Kazunobu

PY - 2012/5

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KW - fullerenes

KW - inhibitors

KW - photolysis

KW - proteins

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Target-selective photodegradation of HIV-1 protease and inhibition of HIV-1 replication in living cells by designed fullerene-sugar hybrids

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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