Target-selective photodegradation of HIV-1 protease and inhibition of HIV-1 replication in living cells by designed fullerene-sugar hybrids

Shuho Tanimoto; Satoshi Sakai; Eriko Kudo; Seiji Okada; Shuichi Matsumura; Daisuke Takahashi; Kazunobu Toshima

doi:10.1002/asia.201101043

Target-selective photodegradation of HIV-1 protease and inhibition of HIV-1 replication in living cells by designed fullerene-sugar hybrids

Shuho Tanimoto, Satoshi Sakai, Eriko Kudo, Seiji Okada, Shuichi Matsumura, Daisuke Takahashi, Kazunobu Toshima

Department of Applied Chemistry

Research output: Contribution to journal › Article › peer-review

21 Citations (Scopus)

Abstract

Sweet degradation: A designed fullerene-sugar hybrid selectively caused the degradation of HIV-1 protease, an important target of anti-HIV therapy. Degradation was achieved at irradiation with long-wavelength UV (365 nm) or visible light (diffuse sunlight) in the absence of any additives and under neutral conditions. Moreover, the hybrid inhibited HIV-1 replication in living cells infected with HIV-1.

Original language	English
Pages (from-to)	911-914
Number of pages	4
Journal	Chemistry - An Asian Journal
Volume	7
Issue number	5
DOIs	https://doi.org/10.1002/asia.201101043
Publication status	Published - 2012 May

Keywords

antiviral agents
fullerenes
inhibitors
photolysis
proteins

ASJC Scopus subject areas

Biochemistry
Organic Chemistry

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Target-selective photodegradation of HIV-1 protease and inhibition of HIV-1 replication in living cells by designed fullerene-sugar hybrids. / Tanimoto, Shuho; Sakai, Satoshi; Kudo, Eriko; Okada, Seiji; Matsumura, Shuichi; Takahashi, Daisuke ; Toshima, Kazunobu.

In: Chemistry - An Asian Journal, Vol. 7, No. 5, 05.2012, p. 911-914.

Research output: Contribution to journal › Article › peer-review

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