Abstract
Sweet degradation: A designed fullerene-sugar hybrid selectively caused the degradation of HIV-1 protease, an important target of anti-HIV therapy. Degradation was achieved at irradiation with long-wavelength UV (365 nm) or visible light (diffuse sunlight) in the absence of any additives and under neutral conditions. Moreover, the hybrid inhibited HIV-1 replication in living cells infected with HIV-1.
| Original language | English |
|---|---|
| Pages (from-to) | 911-914 |
| Number of pages | 4 |
| Journal | Chemistry - An Asian Journal |
| Volume | 7 |
| Issue number | 5 |
| DOIs | |
| Publication status | Published - 2012 May |
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Keywords
- antiviral agents
- fullerenes
- inhibitors
- photolysis
- proteins
ASJC Scopus subject areas
- Chemistry(all)
- Medicine(all)
Cite this
Target-selective photodegradation of HIV-1 protease and inhibition of HIV-1 replication in living cells by designed fullerene-sugar hybrids. / Tanimoto, Shuho; Sakai, Satoshi; Kudo, Eriko; Okada, Seiji; Matsumura, Shuichi; Takahashi, Daisuke; Toshima, Kazunobu.
In: Chemistry - An Asian Journal, Vol. 7, No. 5, 05.2012, p. 911-914.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Target-selective photodegradation of HIV-1 protease and inhibition of HIV-1 replication in living cells by designed fullerene-sugar hybrids
AU - Tanimoto, Shuho
AU - Sakai, Satoshi
AU - Kudo, Eriko
AU - Okada, Seiji
AU - Matsumura, Shuichi
AU - Takahashi, Daisuke
AU - Toshima, Kazunobu
PY - 2012/5
Y1 - 2012/5
N2 - Sweet degradation: A designed fullerene-sugar hybrid selectively caused the degradation of HIV-1 protease, an important target of anti-HIV therapy. Degradation was achieved at irradiation with long-wavelength UV (365 nm) or visible light (diffuse sunlight) in the absence of any additives and under neutral conditions. Moreover, the hybrid inhibited HIV-1 replication in living cells infected with HIV-1.
AB - Sweet degradation: A designed fullerene-sugar hybrid selectively caused the degradation of HIV-1 protease, an important target of anti-HIV therapy. Degradation was achieved at irradiation with long-wavelength UV (365 nm) or visible light (diffuse sunlight) in the absence of any additives and under neutral conditions. Moreover, the hybrid inhibited HIV-1 replication in living cells infected with HIV-1.
KW - antiviral agents
KW - fullerenes
KW - inhibitors
KW - photolysis
KW - proteins
UR - http://www.scopus.com/inward/record.url?scp=84860449379&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84860449379&partnerID=8YFLogxK
U2 - 10.1002/asia.201101043
DO - 10.1002/asia.201101043
M3 - Article
C2 - 22378594
AN - SCOPUS:84860449379
VL - 7
SP - 911
EP - 914
JO - Chemistry - An Asian Journal
JF - Chemistry - An Asian Journal
SN - 1861-4728
IS - 5
ER -