Targeting Cancer Stem Cells-Modulating Embryonic Stem Cell Signaling, Epigenetics, and Tumor Metabolism

Naoko Takebe, Pamela Jo Harris, Yutaka Kondo, Abhilasha Nair, S. Percy Ivy, Hideyuki Saya

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Cancer stem cells (CSC) are important to understand in order to develop solutions to treat tumor metastasis and resistance to therapy. CSCs are characterized by their ability to self-renew and differentiate into tumors, ultimately leading to therapeutic resistance. This chapter summarizes the various potential therapeutic approaches to control CSCs survival and proliferation based on preclinical and clinical study-based rationale. The proposed agents range from investigational, which are still in pre-clinical stage, already in early clinical investigational stage, or already approved for clinical use for other indications. The manuscript covers the agents targeting embryonic stem cell signaling, epigenetic control, cancer metabolism, and induction of epithelial-to-mesenchymal transition (EMT). The combination of therapeutic strategies to reduce bulk tumor populations and to target CSCs population may provide clinically meaningful tumor suppression. The development of new anti-CSC therapeutic agents and the complexity of potential molecular pathways controlling CSC survival are described in this review.

Original languageEnglish
Title of host publicationCancer Stem Cells
PublisherWiley Blackwell
Pages295-317
Number of pages23
Volume9781118356166
ISBN (Electronic)9781118356203
ISBN (Print)9781118356166
DOIs
Publication statusPublished - 2014 Apr 14

Keywords

  • CSC therapeutic targets
  • Cancer stem cells (CSCs)
  • Embryonic stem cell signaling
  • Epigenetics
  • Epithelial-to-mesenchymal transition (EMT)
  • Hedgehog signaling pathway
  • Notch signaling pathway
  • Polycomb-repressive complexes
  • Tumor metabolism
  • Wnt signaling pathway

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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  • Cite this

    Takebe, N., Harris, P. J., Kondo, Y., Nair, A., Percy Ivy, S., & Saya, H. (2014). Targeting Cancer Stem Cells-Modulating Embryonic Stem Cell Signaling, Epigenetics, and Tumor Metabolism. In Cancer Stem Cells (Vol. 9781118356166, pp. 295-317). Wiley Blackwell. https://doi.org/10.1002/9781118356203.ch23