Tau Oligomers

Sumihiro Maeda, Akihiko Takashima

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

The accumulation of tau filaments in neurons is a pathological hallmark of various neurodegenerative diseases, including Alzheimer’s disease. However, it is not the filamentous aggregates themselves, but non-filamentous tau species, tau oligomer, that is thought to be the culprit in tau-mediated neurodegeneration. The definition of and methodology for isolating tau oligomers vary among researchers. Here we describe how tau oligomers are identified, summarize the differences of tau oligomers among research groups, and discuss their hypothesized functions.

Original languageEnglish
Title of host publicationAdvances in Experimental Medicine and Biology
PublisherSpringer
Pages373-380
Number of pages8
DOIs
Publication statusPublished - 2019 Jan 1

Publication series

NameAdvances in Experimental Medicine and Biology
Volume1184
ISSN (Print)0065-2598
ISSN (Electronic)2214-8019

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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