TY - CHAP
T1 - Tau Oligomers
AU - Maeda, Sumihiro
AU - Takashima, Akihiko
N1 - Funding Information:
Acknowledgement The authors thank Dr. Gary Howard for editorial review. This research was partially supported by grants from the Cyclic Innovation for Clinical Empowerment (CiCLE) and the Acceleration Program for Intractable Diseases Research Utilizing Disease-specific iPS Cells from the Japan Agency for Medical Research and Development (AMED) and JSPS to SM.
Publisher Copyright:
© Springer Nature Singapore Pte Ltd. 2019.
PY - 2019
Y1 - 2019
N2 - The accumulation of tau filaments in neurons is a pathological hallmark of various neurodegenerative diseases, including Alzheimer’s disease. However, it is not the filamentous aggregates themselves, but non-filamentous tau species, tau oligomer, that is thought to be the culprit in tau-mediated neurodegeneration. The definition of and methodology for isolating tau oligomers vary among researchers. Here we describe how tau oligomers are identified, summarize the differences of tau oligomers among research groups, and discuss their hypothesized functions.
AB - The accumulation of tau filaments in neurons is a pathological hallmark of various neurodegenerative diseases, including Alzheimer’s disease. However, it is not the filamentous aggregates themselves, but non-filamentous tau species, tau oligomer, that is thought to be the culprit in tau-mediated neurodegeneration. The definition of and methodology for isolating tau oligomers vary among researchers. Here we describe how tau oligomers are identified, summarize the differences of tau oligomers among research groups, and discuss their hypothesized functions.
UR - http://www.scopus.com/inward/record.url?scp=85080901821&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85080901821&partnerID=8YFLogxK
U2 - 10.1007/978-981-32-9358-8_27
DO - 10.1007/978-981-32-9358-8_27
M3 - Chapter
C2 - 32096050
AN - SCOPUS:85080901821
T3 - Advances in Experimental Medicine and Biology
SP - 373
EP - 380
BT - Advances in Experimental Medicine and Biology
PB - Springer
ER -